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The Relationship Between the Clinical Course of Sars-Cov-2 Infections and Expression of Bruton's Tyrosine Kinase Publisher Pubmed



Rezaei M1, 2, 3 ; Babamahmoodi A1, 3 ; Mirahmadi A1 ; Bineshfar N1 ; Mahmoudi S4, 5 ; Ghadimi S1 ; Valizadeh M1 ; Malakouti T1 ; Taheri FT1 ; Mohammadpour H6 ; Azadani FN1 ; Ziai SA7 ; Poorhosseini SM1, 8 ; Marjani M3
Authors
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Authors Affiliations
  1. 1. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Clinical Tuberculosis and Epidemiology Research Center, `National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Biotechnology Centre, Silesian University of Technology, Gliwice, Poland
  6. 6. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Infectious disorders drug targets Published:2025


Abstract

INTRODUCTION: Bruton's Tyrosine Kinase (BTK), an important element for the production of several inflammatory cytokines, may play a role in the pathogenesis of COVID-19. This study aimed to assess BTK gene expression levels in COVID-19 cases based on disease severity and outcome. METHODS: In this study, 33 hospitalized patients with COVID-19 were recruited and divided into two groups based on the severity of the disease: mild to moderate and severe to critical. A blood sample was taken from each patient, peripheral blood mononuclear cells (PBMCs) were extracted, and BTK gene expression was measured. The level of BTK gene expression was compared based on the demographic data, laboratory results, and the severity and outcome of the disease. RESULTS: Among the 33 patients, 22 (66.7%) were male, with nearly half having at least one underlying condition. The severity groups comprised 12 patients in the mild to moderate category and 21 in the severe to critical category, with eight (24.2%) experiencing fatal outcomes. Age, weight, and BMI showed no significant associations with BTK expression. BTK expression was notably lower in severe to critical and ICU-admitted cases, as well as in individuals with low O2 saturation. However, no significant difference in BTK expression was observed between cured and deceased patients (p = 0.117). CONCLUSION: BTK gene expression in PBMCs exhibited an inverse correlation with COVID- 19 severity. However, no difference was found between BTK expression and disease outcome. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.