Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical Impedance Spectroscopy in Endoscopic Procedures Publisher



Dowlatabad HM¹ ; Mahdavi R^{1, 2} ; Miri SR^{2, 3} ; Fattahi MR^{2, 3, 4} ; Ataee H¹ ; Yousefpour N¹ ; Manoochehri N¹ ; Taslimi R⁵ ; Abdolahad M^{1, 3} Show Affiliations
Source: Digestive Diseases and Sciences Published:2025

Abstract

Purpose: Early detection of GI cancer mass is of utmost importance due to the risks of misdiagnoses that occur through standard endoscopic evaluation. Methods: In this research, a real-time intra-endoscopic electrical diagnostic probe has been introduced to discriminate high-risk excision-required lesions utilizing a modified endoscopic biopsy forceps as a non-invasive method. Results: By testing on 52 patients who had undergone endoscopic biopsy with a total of 18 high-risk lesions, the invented device named Electrical Endoscopic Mass Characterizer (EEMC), showed %94.7 sensitivity, %93.9 specificity, and %94.2 accuracy (p < 0.01) based on histopathological evaluations of removed specimens as the gold standard. Conclusions: EEMC can be utilized as a precise complementary device during endoscopic evaluation for improving the accuracy of early-stage GI cancer detection with no interruptions in the routine procedure. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.