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Cognitive Functions in Epileptic Patients on Lamotrigine and Other Antiepileptic Drugs



Akhlaghi Z1 ; Cheraghmakani H2 ; Batouli SAH3 ; Khalifeh S4 ; Abdi R5 ; Ashayeri H6
Authors
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Authors Affiliations
  1. 1. Cognitive Neuroscience, Institute for Cognitive Science Studies, Tehran, Iran
  2. 2. Department of Neurology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Biomedical Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Department of Basic Sciences in Rehabilitation, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Mazandaran University of Medical Sciences Published:2019

Abstract

Background and purpose: Anti-epileptic drugs (AEDs) can affect cognitive functions. The purpose of this study was to investigate the effects of lamotrigine (LT) on cognitive functions of patients with epilepsy. Materials and methods: A study with retrospective cohort design was carried out in which we assessed cognitive functions of 20 IGE patients attending Sari Bu Ali Hospital, and 12 healthy subjects. The control group was matched for age, sex, and educational level. Standardized neuropsychological tests were used to evaluate cognitive functions. The study was analyzed applying one-way ANOVA and Tukey Test in SPSS. Results: Compared with the control group, LT group showed poor performance in Stroop test and verbal fluency test-semantic test (P<0.05). The group on other drugs were also found to have poor performance in verbal fluency test (phonetic and semantic), forward digit span task, and Stroop test compared with those of the control group (P<0.05). Conclusion: Compared with LT, other AEDs had more adverse effects on cognitive functions which could be due to their effect on channels and release changing stimulatory neurotransmitters. © 2019, Mazandaran University of Medical Sciences. All rights reserved.
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