Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients

Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients Publisher Pubmed

Sadeghipour A^{1, 2} ; Taha SR² ; Zadeh MS² ; Kosari F³ ; Babaheidarian P¹ ; Fattahi F⁴ ; Abdi N¹ ; Tajik F^{2, 5}

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1. Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
3. Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Clinical Research Development Unit of Ayatollah-Khansari Hospital, Arak University of Medical Sciences, Arak, Iran
5. Department of Surgery, University of California, Irvine Medical Center, Orange, CA, United States

Source: Applied Immunohistochemistry and Molecular Morphology Published:2024

Abstract

Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) in adults. Although studies regarding the association between the expression of Ki-67, CD10, BCL6, and MUM1 proteins, as well as c-MYC amplification and EBV status with clinicopathologic characteristics have rapidly progressed, their co-expression and prognostic role remain unsatisfactory. Therefore, this study aimed to investigate the association between the expression of all markers and clinicopathologic features and their prognostic value in DLBCL. Also, the co-expression of markers was investigated. Methods: The protein expression levels and prognostic significance of Ki-67, CD10, BCL6, and MUM1 were investigated with clinical follow-up in a total of 53 DLBCL specimens (including germinal center B [GCB] and activated B cell [ABC] subtypes) as well as adjacent normal samples using immunohistochemistry (IHC). Besides, the clinical significance and prognostic value of c-MYC and EBV status were also evaluated through chromogenic in situ hybridization (CISH), and their correlation with other markers was also assessed. Results: The results demonstrated a positive correlation between CD10 and BCL6 expression, with both markers being associated with the GCB subtype (P < 0.001 and P = 0.001, respectively). Besides, we observe a statistically significant association between MUM1 protein expression and clinicopathologic type (P < 0.005) as well as a positive association between c-MYC and recurrence (P = 0.028). Our survival analysis showed that patients who had responded to R-CHOP treatment had better overall survival (OS) and progression-free survival (PFS) than those who did not. Conclusion: Collectively, this study’s results add these markers’ value to the existing clinical understanding of DLBCL. However, further investigations are needed to explore markers’ prognostic and biological roles in DLBCL patients. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Mohammad Reza Keramati (1)

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Style	Citing Format
MLA	Sadeghipour A, et al.. "Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients." Applied Immunohistochemistry and Molecular Morphology, vol. 32, no. 7, 2024, pp. 309-321.
APA	Sadeghipour A, Taha SR, Zadeh MS, Kosari F, Babaheidarian P, Fattahi F, Abdi N, Tajik F (2024). Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients. Applied Immunohistochemistry and Molecular Morphology, 32(7), 309-321.
Chicago	Sadeghipour A, Taha SR, Zadeh MS, Kosari F, Babaheidarian P, Fattahi F, Abdi N, Tajik F. "Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients." Applied Immunohistochemistry and Molecular Morphology 32, no. 7 (2024): 309-321.
Harvard	Sadeghipour A et al. (2024) 'Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients', Applied Immunohistochemistry and Molecular Morphology, 32(7), pp. 309-321.
Vancouver	Sadeghipour A, Taha SR, Zadeh MS, Kosari F, Babaheidarian P, Fattahi F, et al.. Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients. Applied Immunohistochemistry and Molecular Morphology. 2024;32(7):309-321.
BibTex	@article{ author = {Sadeghipour A and Taha SR and Zadeh MS and Kosari F and Babaheidarian P and Fattahi F and Abdi N and Tajik F}, title = {Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients}, journal = {Applied Immunohistochemistry and Molecular Morphology}, volume = {32}, number = {7}, pages = {309-321}, year = {2024} }
RIS	TY - JOUR AU - Sadeghipour A AU - Taha SR AU - Zadeh MS AU - Kosari F AU - Babaheidarian P AU - Fattahi F AU - Abdi N AU - Tajik F TI - Expression and Clinical Significance of Ki-67, Cd10, Bcl6, Mum1, C-Myc, and Ebv in Diffuse Large B Cell Lymphoma Patients JO - Applied Immunohistochemistry and Molecular Morphology VL - 32 IS - 7 SP - 309 EP - 321 PY - 2024 ER -

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