Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Prostate Cancer Radiotherapy on Testosterone Level: A Systematic Review and Meta-Analysis Publisher Pubmed



Mortezaee K1 ; Motallebzadeh E2 ; Milajerdi A3, 4 ; Farhood B2 ; Najafi M5 ; Sahebkar A6, 7, 8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  2. 2. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran, University of Medical Sciences, Tehran, Iran
  4. 4. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Halal Research Center of IRI, FDA, Tehran, Iran
  7. 7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Anti-Cancer Agents in Medicinal Chemistry Published:2020


Abstract

Introduction: In the current study, a systematic search and meta-analysis were performed to evaluate the effect of prostate cancer radiotherapy on testosterone levels of patients. Methods: To illuminate the effect of radiotherapy on the testosterone level of prostate cancer patients, a systematic search was conducted in accordance with the PRISMA guideline in electronic databases of Scopus, Embase, PubMed, Web of Science, and clinical trials up to December 2018 using relevant keywords. Based on a certain set of inclusion and exclusion criteria, 12 eligible studies that had data on the testosterone level following prostate cancer radiotherapy were included in the meta-analysis. Results: According to the various techniques of prostate cancer radiotherapy, the dose values scattered to the testicular tissues ranged from 0.31 to 10 Gy. Combining the findings from 12 studies, it was found that prostate cancer radiotherapy leads to a significant reduction in the testosterone level (Weighted Mean Difference [WMD]:-51.38 ng/dL, 95% CI:-75.86,-26.90, I2=0.0%, P<0.05). Furthermore, subgroup analysis by the patient number showed a significant reduction in the testosterone level at patient number < 50 (WMD:-80.32 ng/dL, 95% CI:-125.10,-35.55, I2= 0.0%) and 50 < patient number < 100 (WMD:-46.99 ng/dL, 95% CI:-87.15,-6.82, I2= 0.0%). Subgroup analysis based on treatment technique type revealed a significant reduction in testosterone level after conventional radiotherapy (WMD:-56.67, 95% CI:-100.45,-12.88, I2= 34.3%) and IMRT/SBRT technique (WMD:-57.42, 95% CI:-99.39,-15.46, I2= 0.0%) in comparison with the proton therapy (WMD: 0.00, 95% CI:-80.24, 80.24). Conclusion: The findings showed a significant decrease in the testosterone level of prostate cancer patients after radiotherapy compared with pre-treatment levels. © 2020 Bentham Science Publishers.
Related Docs
1. A Systematic Review of Radiation-Induced Testicular Toxicities Following Radiotherapy for Prostate Cancer, Journal of Cellular Physiology (2019)
2. Reservation of Male Fertility in Patients Undergoing Pelvic Irradiation, Reports of Practical Oncology and Radiotherapy (2023)
3. Thermoluminescence Dosimetry of the Dose Received by Scrotum and Testes in Radiotherapy of Rectal Cancer, Compared to the Point Doses Calculated by 3D-Planning Software, Physica Medica (2018)
4. The Incidence of Prostate Cancer in Iran: A Systematic Review and Meta-Analysis, Prostate International (2018)
5. Molecular Characterization of Kras, Braf, and Egfr Genes in Cases With Prostatic Adenocarcinoma; Reporting Bioinformatics Description and Recurrent Mutations, Clinical Laboratory (2015)
6. Incidence and Mortality of Various Cancers in Iran and Compare to Other Countries: A Review Article, Iranian Journal of Public Health (2018)
7. Prostate Cancer in Iran: Trends in Incidence and Morphological and Epidemiological Characteristics, Asian Pacific Journal of Cancer Prevention (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Reza Nowroozi (1)
Farshid Farhan (1)