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A Novel Admittometric Sensor for Determination of Theophylline Using Fft Coulometric Admittance Voltammetry and Flow Injection Analysis Publisher



Norouzi P1, 2 ; Shahabi S1 ; Aghazadeh M3 ; Larijani B4 ; Ghaheri N1
Authors
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Materials and Nuclear Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-834, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Electrochemical Science Published:2017


Abstract

A new electrochemical analysis was established for the determination of Theophylline using FFT Coulometric Admittance Voltammetry (FFTCAV) technique and a new nanocomposite electrode, which was placed in a flow-injection system. The electrode was constructed by deposition of gold nanoparticles on mixture of multiwall carbon nanotube and chitosan casted on a carbon paste electrode containing SiC NPs and ionic liquid. The analyte response was calculated to obtain the charge changes, which was integration of the admittance in selected potential range, where the background admittance was subtracted. The electrode surface characterization was studied by electrochemical impedance spectroscopy and scanning electron microscopy techniques. As result, application of the new nanocomposite catalyzed electron transfer and causes a significant enhancement in the analyte response. It was found that the response enhanced proportionally with concentrations of Theophylline in a range from 2 to 100 nM, with a detection limit of 0.39 nM. © 2017 The Authors.