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The Up-Regulation of Markers of Adipose Tissue Fibrosis by Visfatin in Pre-Adipocytes As Well As Obese Children and Adolescents Publisher Pubmed



Ezzatimobaser S1 ; Malekpourdehkordi Z2 ; Nourbakhsh M3 ; Tavakoliyaraki M1 ; Ahmadpour F4 ; Golpour P1 ; Nourbakhsh M3
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Hazrat Aliasghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Cytokine Published:2020


Abstract

Adipocytes are surrounded by a three-dimensional network of extracellular matrix (ECM) proteins. Aberrant ECM accumulation and remodeling leads to adipose tissue fibrosis. Visfatin is one of the adipocytokines that is increased in obesity and is implicated in insulin resistance. The objective of this study was to investigate the effect of visfatin on major components of ECM remodeling. In this study, plasma levels of both endotrophin and visfatin in obese children and adolescents were significantly higher than those in control subjects and they showed a positive correlation with each other. Treatment of 3T3-L1 pre-adipocytes with visfatin caused significant up-regulation of Osteopontin (Opn), Collagen type VI (Col6), matrix metalloproteinases MMP-2 and MMP-9. By using inhibitors of major signaling pathways it was shown that visfatin exerted its effect on Col6a3 gene expression through PI3K, JNK, and NF-кB pathways, while induced Opn gene expression via PI3K, JNK, MAPK/ERK, and NOTCH1. Our conclusion is that, the relationship between visfatin, endotrophin and insulin resistance parameters in obesity as well as increased expression of ECM proteins by visfatin suggests adipose tissue fibrosis as a mechanism for devastating effects of visfatin in obesity. © 2020 Elsevier Ltd
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