The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)

The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231) Publisher Pubmed

Eivazy P^{1, 2} ; Atyabi F⁴ ; Jadidiniaragh F⁵ ; Aghebati Maleki L² ; Miahipour A⁶ ; Abdolalizadeh J¹ ; Yousefi M^{2, 3}

Show Affiliations

1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran
3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4. Department of Pharmaceutics, Faculty of Pharmacy, Novel Drug Delivery System Laboratory, Medical Sciences University, Tehran, Iran
5. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tabriz, Iran
6. Department of Medical Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017

Abstract

High-mobility group protein two (HMGA2), a nonhistone nuclear-binding protein and its downregulators; vimentin, matrix metallopeptidase-9 (MMP-9), and E-cadherin are shown to contribute to tumor progression and metastasis. Thus, in this study, we checked simultaneous delivery of HMGA-2 siRNA and the anticancer drug doxorubicin to enhance the anticancer treatment effects. For this purpose, we used MTT assay and real-time polymerase chain reaction (RT-PCR). Our results showed that dual delivery of Dox and HMGA-2 siRNA by trimethyl chitosan (TMC) significantly inhibited breast cancer cells growth. Additionally, the delivery of siRNA significantly silenced HMGA-2, vimentin, and MMP9 mRNAs, but led to overexpression of E-cadherin mRNA. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Eivazy P, et al.. "The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)." Artificial Cells# Nanomedicine and Biotechnology, vol. 45, no. 5, 2017, pp. 889-896.
APA	Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, Yousefi M (2017). The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231). Artificial Cells# Nanomedicine and Biotechnology, 45(5), 889-896.
Chicago	Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, Yousefi M. "The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)." Artificial Cells# Nanomedicine and Biotechnology 45, no. 5 (2017): 889-896.
Harvard	Eivazy P et al. (2017) 'The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)', Artificial Cells# Nanomedicine and Biotechnology, 45(5), pp. 889-896.
Vancouver	Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, et al.. The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231). Artificial Cells# Nanomedicine and Biotechnology. 2017;45(5):889-896.
BibTex	@article{ author = {Eivazy P and Atyabi F and Jadidiniaragh F and Aghebati Maleki L and Miahipour A and Abdolalizadeh J and Yousefi M}, title = {The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {45}, number = {5}, pages = {889-896}, year = {2017} }
RIS	TY - JOUR AU - Eivazy P AU - Atyabi F AU - Jadidiniaragh F AU - Aghebati Maleki L AU - Miahipour A AU - Abdolalizadeh J AU - Yousefi M TI - The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231) JO - Artificial Cells# Nanomedicine and Biotechnology VL - 45 IS - 5 SP - 889 EP - 896 PY - 2017 ER -

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