Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Letter to the Editor: Comments on “Association Between the Icam-1 Gene Polymorphism and Coronary Heart Disease Risk: A Meta-Analysis” Publisher Pubmed



Gholami M1, 2 ; Amoli MM1 ; Sharifi F3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Bioscience Reports Published:2019


Abstract

Yin et al. (Bioscience Reports (2019) 39, BSR20180923) recently published a meta-analysis about the association between the K469E (rs5498) polymorphism and risk of coronary heart disease (CHD). Authors included 14 studies based on their inclusion criteria. They indicated that only studies which their genotyping data were in Hardy–Weinberg equilibrium (HWE) were included in their meta-analysis. They also tested HWE for these studies and found all the control groups in HWE. As their main finding, they concluded that ‘K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD amongst Chinese and Caucasians populations’. However, there seems to be presenting some mistakes in HWE test which strongly affects included studies and the final conclusion. Here we aim to comment on the issue. © 2019 The Author(s).