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The Serum Level of Oxidative Stress and Antioxidant Markers in Patients With Psoriasis: A Cross-Sectional Study



Shakoei S1 ; Nakhjavani M2 ; Mirmiranpoor H2 ; Motlagh MA1 ; Azizpour A3 ; Abedini R3
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Authors Affiliations
  1. 1. Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical and Aesthetic Dermatology Published:2021

Abstract

BACKGROUND: Psoriasis is a chronic, immunemediated, inflammatory disease. Previous studies have indicated a possible role of oxidative stress in the pathogenesis of psoriasis. OBJECTIVE: We sought to compare special oxidative stress and antioxidant markers in psoriatic patients. METHODS: This study included 35 patients with psoriasis and 35 healthy controls. Serum levels of oxidant markers, including advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs), as well as antioxidant enzymes, including lecithincholesterol acyltransferase (LCAT), paraoxonase-1 (PON1), and ferric-reducing ability of plasma (FRAP), were measured. RESULTS: The mean age of the subjects was 39.63±13 years in the case group and 39.37±12.62 years in the control group (p=0.92). The mean Psoriasis Area and Severity Index (PASI) scores of these groups were 15.27 and 10.47. The mean levels of fasting blood sugar and C-reactive protein were significantly higher in the case group than the control group (p=0.04 and p=0.02, respectively). Moreover, the mean levels of AGEs and AOPPs in the case group were significantly higher than in the control group (p=0.001), while the mean levels of FRAP, PON1, and LCAT were significantly lower in the case group than in the control group (p=0.001). There was no significant association between PASI and oxidant or antioxidant markers, except for AOPP, which had a negative association with PASI. CONCLUSIONS: Our findings suggest an imbalance among oxidative stress and antioxidant markers in the pathogenesis of psoriasis. The oxidant-antioxidant enzymatic system is impaired in psoriasis as a result of increased oxidant products and reduced antioxidant activity. © 2021 Matrix Medical Communications. All rights reserved.
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