A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome

A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome Publisher

Mosayebi Z¹ ; Kadivar M¹ ; Taheriderakhsh N² ; Nariman S² ; Marashi SM³ ; Farsi Z²

Show Affiliations

1. Department of Neonatology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Neonatology, ArashWomen's Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Comprehensive Pediatrics Published:2017

Abstract

Background: The present study was conducted to investigate and compare the effectiveness of the minimally invasive surfactant therapy (MIST) and the INSURE technique (Intubation, Surfactant administration, and extubation) in spontaneously breathing preterm infants. Methods: Preterm infants (28-34 weeks of gestation) born with respiratory distress syndrome between April 2013 and February 2014 were randomly selected to receive 200 mg/kg of surfactant (Curosurf) using either MIST or INSURE techniques. In the MIST group, surfactant was instilled via a thin tracheal catheter (5-f) that was then removed. In the INSURE group, the infants were first intubated, administered surfactant through passing a feeding tube through the endotracheal tube, and then extubated after 30 seconds of positive pressure ventilation. Nasal CPAP for respiratory support continued in both groups after performing the procedures. The amounts of supplemental oxygen required, intensive care requirements, and outcomes were compared between the two groups. Results: The present study examined 27 infants in the MIST group and 26 in the INSURE group. The amount of oxygen required by the MIST group was consistently less than that in the other group over the first 48 hours of life. The overall mean FiO2 was 42.5 ± 19.6 in the MIST group and 48.4±21.6 in the INSURE group (P = 0.009). The mean duration of stay in the neonatal intensive care unit was 7.3±7.2 days in the MIST group and 9±10.4 days in the INSURE group (P = 0.81). In terms of early and delayed complications, no differences were observed between the two groups. Conclusions: The MIST technique is a feasible and effective alternative to the INSURE technique and is advised to be performed with impunity in preterm infants (28 to 34 weeks of gestation). © 2017, Journal of Comprehensive Pediatrics.

2. Predictors of Success Rate in Different Initial Respiratory Supports in Very Low Birthweight Infants With Respiratory Distress, Archives of Iranian Medicine (2020)

3. Evaluation of Initial Respiratory Support Strategies in Vlbw Neonates With Rds, Archives of Iranian Medicine (2017)

Experts (# of related papers)

Ahmadreza Shamshiri (2)

Style	Citing Format
MLA	Mosayebi Z, et al.. "A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome." Journal of Comprehensive Pediatrics, vol. 8, no. 4, 2017, pp. -.
APA	Mosayebi Z, Kadivar M, Taheriderakhsh N, Nariman S, Marashi SM, Farsi Z (2017). A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome. Journal of Comprehensive Pediatrics, 8(4), -.
Chicago	Mosayebi Z, Kadivar M, Taheriderakhsh N, Nariman S, Marashi SM, Farsi Z. "A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome." Journal of Comprehensive Pediatrics 8, no. 4 (2017): -.
Harvard	Mosayebi Z et al. (2017) 'A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome', Journal of Comprehensive Pediatrics, 8(4), pp. -.
Vancouver	Mosayebi Z, Kadivar M, Taheriderakhsh N, Nariman S, Marashi SM, Farsi Z. A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome. Journal of Comprehensive Pediatrics. 2017;8(4):-.
BibTex	@article{ author = {Mosayebi Z and Kadivar M and Taheriderakhsh N and Nariman S and Marashi SM and Farsi Z}, title = {A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome}, journal = {Journal of Comprehensive Pediatrics}, volume = {8}, number = {4}, pages = {-}, year = {2017} }
RIS	TY - JOUR AU - Mosayebi Z AU - Kadivar M AU - Taheriderakhsh N AU - Nariman S AU - Marashi SM AU - Farsi Z TI - A Randomized Trial Comparing Surfactant Administration Using Insure Technique and the Minimally Invasive Surfactant Therapy in Preterm Infants (28 to 34 Weeks of Gestation) With Respiratory Distress Syndrome JO - Journal of Comprehensive Pediatrics VL - 8 IS - 4 SP - EP - PY - 2017 ER -

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