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Acute Sickle Cell Hepatopathy: A Case Report and Literature Review Publisher Pubmed



Hassanzadeh M1 ; Sanat ZM2 ; Khayatian S2 ; Sotoudeheian M3 ; Shahbazian A4 ; Hoseini S5
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Colorectal Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
  2. 2. Department of Internal Medicine, School of Medicine, Digestive Diseases Research Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of the National Medical Association Published:2024


Abstract

Sickle cell disease (SCD) is an inherited hemoglobinopathy with protean clinical manifestations. The liver could be affected by various SCD-associated complications of an overlapping nature. The clinical presentations of sickle cell hepatopathy range from clinically asymptomatic patients to those with life-threatening complications. Herein we report an SCD patient who presented with right upper quadrant abdominal pain and jaundice, eventually diagnosed as a self-limited form of acute sickle cell hepatopathy with overlapping features of acute hepatic crisis and benign intrahepatic cholestasis. Using this patient as an illustration, we will review the spectrum of hepatobiliary presentations in the SCD population. © 2024