The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial

The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial Publisher

Asgari S¹ ; Behnaz F² ; Ommi D³ ; Zandpazandi S⁴ ; Mirahmadi Eraghi M^{4, 5, 6, 7}

Show Affiliations

1. Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Student Research Committee, School of Medicine, Islamic Azad University, Qeshm International Branch, Qeshm, Iran
6. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Trends in Anaesthesia and Critical Care Published:2023

Abstract

Background: Dexmedetomidine is an α2-adrenoceptor agonist with good sedative effects with no cardiovascular instability or respiratory depression, and it might help facilitate endotracheal intubation and inhibit hemodynamic responses. Aim: The current study assessed how intravenous Dexmedetomidine affected cardiovascular response and endotracheal intubation in opium-addict patients. Materials and methods: This study is a clinically randomized, double-blind, controlled trial. One hundred patients diagnosed with supratentorial brain tumors undergoing tumor resection surgery with general anesthesia entered this study. One group received Dexmedetomidine (1/μg/kg for 10 min) before induction of anesthesia. The exact amount of normal saline (placebo) was administered in the second group. The two groups were analyzed statistically regarding blood pressure, heart rate, and bispectral index score, recorded 1 min before and 1 min after intubation. The statistical tests used for analysis are the student T-test, Mann-Whitney non-parametric test, the chi-square test, and Fisher's exact test. Results: The intervention group's heart rate, systolic blood pressure, and bispectral index score decreased 1 min after anesthesia induction and intubation compared to the control group. Diastolic blood pressure after induction of anesthesia was not significantly different between the two groups; however, it decreased following the intervention after intubation (p > 0.05). Conclusion: Compared to the control group, Dexmedetomidine suppressed hemodynamic response and bispectral index score in opium-addict patients. © 2023 Elsevier Ltd

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Style	Citing Format
MLA	Asgari S, et al.. "The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial." Trends in Anaesthesia and Critical Care, vol. 53, no. , 2023, pp. -.
APA	Asgari S, Behnaz F, Ommi D, Zandpazandi S, Mirahmadi Eraghi M (2023). The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial. Trends in Anaesthesia and Critical Care, 53(), -.
Chicago	Asgari S, Behnaz F, Ommi D, Zandpazandi S, Mirahmadi Eraghi M. "The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial." Trends in Anaesthesia and Critical Care 53, no. (2023): -.
Harvard	Asgari S et al. (2023) 'The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial', Trends in Anaesthesia and Critical Care, 53(), pp. -.
Vancouver	Asgari S, Behnaz F, Ommi D, Zandpazandi S, Mirahmadi Eraghi M. The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial. Trends in Anaesthesia and Critical Care. 2023;53():-.
BibTex	@article{ author = {Asgari S and Behnaz F and Ommi D and Zandpazandi S and Mirahmadi Eraghi M}, title = {The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial}, journal = {Trends in Anaesthesia and Critical Care}, volume = {53}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Asgari S AU - Behnaz F AU - Ommi D AU - Zandpazandi S AU - Mirahmadi Eraghi M TI - The Effect of Dexmedetomidine on Suppression of the Bispectral Index Score and Hemodynamic Response During Laryngoscopy and Intubation in Addicted Patients in Supratentorial Brain Tumor Surgery, a Randomized Double-Blinded Controlled Trial JO - Trends in Anaesthesia and Critical Care VL - 53 IS - SP - EP - PY - 2023 ER -

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