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An Alternative Solvent for Electrospinning of Fibrinogen Nanofibers Publisher Pubmed



Mirzaeiparsa MJ1 ; Ghanizadeh A2 ; Ebadi MTK3 ; Faridimajidi R1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Blood Bank, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Bio-Medical Materials and Engineering Published:2018


Abstract

Fibrinogen plays a necessary role in blood clotting and wound healing. In this study, a new solvent mixture of formic acid/acetic acid with low toxicity was investigated as an alternative solvent for fibrinogen electrospinning. The nanofibers were analyzed by scanning electron microscope (SEM), simultaneous thermal analysis (STA) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The results showed that when the ratio of formic acid to acetic acid was 75/25 (v/v) the finest defect-free fibres with diameters ranging from 184 ± 37 to 241 ± 70 nm were obtained. In addition, the average fibre diameters increase with increasing concentration of fibrinogen from 10wt% to 12wt%. It is concluded that solvent mixture consisting of formic acid/acetic acid can be a great solvent for electrospinning of fibrinogen and is able to produce nanofiber structures. © 2018 - IOS Press and the authors. All rights reserved
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