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Melatonin Attenuated the Behavioral Despair Induced by Acute Neurogenic Stress Through Blockade of N-Methyl D-Aspartate Receptors in Mice Publisher



Hajmirzaeyian A1, 2 ; Chamanara M2 ; Rashidian A1 ; Shakyba S1, 2 ; Nassireslami E2 ; Akhavansigari R3
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neurosurgery, University Medical Center Tuebingen, Germany

Source: Heliyon Published:2021


Abstract

Melatonin; Acute foot shock stress; NMDA receptor; Behavioral despair; Mice. © 2021 The Author(s); It has been well documented that administration of melatonin could reveal antidepressant-like effect in rodents. However, the protective effect of melatonin on stress-induced depression/anxiety and its underlying mechanism is yet to be understood. In this regard, in the current study, acute foot-shock stress (FSS) was used to evaluate the antidepressant-like effect of melatonin on neurogenic stress-induced depression in mice. Behavioral evaluation was done by using the forced swimming test (FST) and Open-field test (OFT). Melatonin, MK-801, and ketamine (NMDA receptor antagonists), and NMDA (NMDA receptor agonist) were used to elucidate any association between melatonin and NMDA pathway in behavioral despair induced by acute-FSS. Applying acute-FSS to mice significantly induced depressant-like behavior in FST without any significant impact on locomotor activity in the OFT. We observed that melatonin (dose-dependently) significantly improved the depressant-like effect of FSS, but it did not impact the locomotion in animals. Acute injection of MK-801 at sub-effective doses (0.01 mg/kg) or ketamine (0.1 mg/kg) potentiated the antidepressant-like effect of a sub-effective dose of melatonin. However, the sub-effective dose of NMDA (30 mg/kg) abolished the protective effect of melatonin on the behavioral profile of stressed animals. Our results could reflect the antidepressant-like effect of melatonin on neurogenic stress-induced depressive behaviors in mice. Also, our results showed that NMDA receptors could be involved in the antidepressant-like effect of melatonin. © 2021 The Author(s)
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