Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease

Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease Pubmed

Khaloo P¹ ; Alemi H¹ ; Mansournia MA² ; Rabizadeh S¹ ; Salehi SS¹ ; Blaha MJ³ ; Mirbolouk MH³ ; Mirmiranpour H¹ ; Esteghamati A¹ ; Nakhjavani M¹

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1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, Baltimore, MD, United States

Source: Archives of Iranian Medicine Published:2019

Abstract

Background: We investigated the association of estimated glomerular filtration rate (eGFR) with Framingham risk score (FRS), and actual cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM). We also assessed improvement in FRS for prediction of CVD after inclusion of eGFR and albuminuria. Methods: A total of 571 patients with T2DM and mean age 55 were divided into 2 groups based on the presence of CVD. Participants without CVD were then divided into three groups according to FRS. CVD is defined as an episode of CCU admission, Myocardial infarction, history of coronary artery bypass graft surgery or percutaneous intervention. FRS is calculated using the Wilson 1998 Circulation equation, which includes age, sex, high blood pressure, smoking, high-density lipoprotein (HDL), total cholesterol and diabetes as components to assess CVD risk in 10 years. Results: An inverse adjusted association between eGFR and prevalent CVD was confirmed by multiple logistic regression analysis (OR = 0.84, 95% CI: 0.74, 0.94, P = 0.03). We observed every 10 mL/min/1.73 m2 decrease in eGFR is related to 3% increase in FRS in patients without chronic kidney disease (CKD) (coefficient =-0.03, P < 0.001). The association between FRS and GFR and also CVD and eGFR were not significant in patients with CKD (P = 0.12; P = 0.17, respectively). Predictive values for FRS components with and without considering eGFR and albuminuria were calculated (0.74 and 0.75, respectively). Conclusion: Inclusion of eGFR and albuminuria in the FRS formula did not improve the predictive value of the model. We showed an inverse association between eGFR and FRS in early stages of diabetic kidney disease, which was lost in patients with CKD. © 2019 The Author(s).

2. Eight Weeks of Vitamin C Supplementation Restores the Lost Correlation Between Serum Leptin and C-Reactive Protein (Crp) in Patients With Type 2 Diabetes; a Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial, Current Pharmaceutical Design (2023)

3. Absence of a Positive Correlation Between Crp and Leptin in Rheumatoid Arthritis, Heliyon (2016)

4. Global, Regional, and National Burden of Chronic Kidney Disease, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017, The Lancet (2020)

5. The Lost Correlation Between Heat Shock Protein 70 (Hspa1a) and Plasminogen Activator Inhibitor-1 in Patients With Type 2 Diabetes and Albuminuria, Cell Stress and Chaperones (2016)

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Style	Citing Format
MLA	Khaloo P, et al.. "Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease." Archives of Iranian Medicine, vol. 22, no. 2, 2019, pp. 91-98.
APA	Khaloo P, Alemi H, Mansournia MA, Rabizadeh S, Salehi SS, Blaha MJ, Mirbolouk MH, Mirmiranpour H, Esteghamati A, Nakhjavani M (2019). Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease. Archives of Iranian Medicine, 22(2), 91-98.
Chicago	Khaloo P, Alemi H, Mansournia MA, Rabizadeh S, Salehi SS, Blaha MJ, Mirbolouk MH, Mirmiranpour H, Esteghamati A, Nakhjavani M. "Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease." Archives of Iranian Medicine 22, no. 2 (2019): 91-98.
Harvard	Khaloo P et al. (2019) 'Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease', Archives of Iranian Medicine, 22(2), pp. 91-98.
Vancouver	Khaloo P, Alemi H, Mansournia MA, Rabizadeh S, Salehi SS, Blaha MJ, et al.. Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease. Archives of Iranian Medicine. 2019;22(2):91-98.
BibTex	@article{ author = {Khaloo P and Alemi H and Mansournia MA and Rabizadeh S and Salehi SS and Blaha MJ and Mirbolouk MH and Mirmiranpour H and Esteghamati A and Nakhjavani M}, title = {Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease}, journal = {Archives of Iranian Medicine}, volume = {22}, number = {2}, pages = {91-98}, year = {2019} }
RIS	TY - JOUR AU - Khaloo P AU - Alemi H AU - Mansournia MA AU - Rabizadeh S AU - Salehi SS AU - Blaha MJ AU - Mirbolouk MH AU - Mirmiranpour H AU - Esteghamati A AU - Nakhjavani M TI - Loss of Inverse Association Between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease JO - Archives of Iranian Medicine VL - 22 IS - 2 SP - 91 EP - 98 PY - 2019 ER -

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