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Elevated Serum Level of Il-4 in Neuromyelitis Optica and Multiple Sclerosis Patients Publisher Pubmed



Tahani S1, 2 ; Dehghani L3 ; Jahanbaniardakani H4 ; Shaygannejad V1 ; Fazli A5 ; Hamidavi A5 ; Eskandari N5
Authors
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Authors Affiliations
  1. 1. Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Sciences, School of Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran
  3. 3. Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Isfahan Medical Students Research Center (IMSRC), Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Immunoassay and Immunochemistry Published:2019


Abstract

Mediators have important roles in the pathogenesis of autoimmune diseases. Interleukin 4 (IL-4) is one of the most important cytokines that has a regulatory effect on immune cells. In the current study, the serum level of IL-4 was assessed in the newly diagnosed neuromyelitis optica (NMO) and multiple sclerosis (MS) patients compared to healthy subjects. ELISA technique was used for assessment of the serum level of IL-4, and data analysis was performed by SPSS software. Serum level of IL-4 was elevated in both NMO and MS patients compared with healthy individuals (P <.001), but no statistically significant difference was identified between MS and NMO patients (P =.071). Furthermore, gender (female) and AQP4-Ab had significant impacts on the level of IL-4 in NMO patients (P <.001). These data show the crucial role of IL-4 in the pathogenesis of NMO and MS diseases. However, we suggest future studies to investigate the serum level of IL-4 in NMO and MS patients to clarify more roles of this cytokine in the pathogenesis of both diseases. © 2019, © 2019 Taylor & Francis.
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