Elevated Serum Level of Il-4 in Neuromyelitis Optica and Multiple Sclerosis Patients Publisher Pubmed



Tahani S^{1, 2} ; Dehghani L³ ; Jahanbaniardakani H⁴ ; Shaygannejad V¹ ; Fazli A⁵ ; Hamidavi A⁵ ; Eskandari N⁵
Source: Journal of Immunoassay and Immunochemistry Published:2019

Abstract

Mediators have important roles in the pathogenesis of autoimmune diseases. Interleukin 4 (IL-4) is one of the most important cytokines that has a regulatory effect on immune cells. In the current study, the serum level of IL-4 was assessed in the newly diagnosed neuromyelitis optica (NMO) and multiple sclerosis (MS) patients compared to healthy subjects. ELISA technique was used for assessment of the serum level of IL-4, and data analysis was performed by SPSS software. Serum level of IL-4 was elevated in both NMO and MS patients compared with healthy individuals (P <.001), but no statistically significant difference was identified between MS and NMO patients (P =.071). Furthermore, gender (female) and AQP4-Ab had significant impacts on the level of IL-4 in NMO patients (P <.001). These data show the crucial role of IL-4 in the pathogenesis of NMO and MS diseases. However, we suggest future studies to investigate the serum level of IL-4 in NMO and MS patients to clarify more roles of this cytokine in the pathogenesis of both diseases. © 2019, © 2019 Taylor & Francis.