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Effect of Vitamins A, E, C and Omega-3 Fatty Acids Supplementation on the Level of Catalase and Superoxide Dismutase Activities in Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Tabei SMB1 ; Fakher S2 ; Djalali M2 ; Javanbakht MH2 ; Zarei M2 ; Derakhshanian H2 ; Sadeghi MR3 ; Mostafavi E4 ; Kargar F5
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Reproductive Endocrinology and Embryology, Avesina Research Institute, Tehran, Iran
  4. 4. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Bratislava Medical Journal Published:2015


Abstract

Background: Since free radicals and antioxidant enzymes may play an important role in the development of diabetes, the present study was designed to assess the effect of supplementation with vitamins A, E and C and ω-3 fatty acids on catalase and superoxide dismutase activity in streptozotocin (STZ)-induced diabetic rats. Methods: A total of 64 male Wistar rats weighing 250 g were divided into four groups as normal control, diabetic control, diabetic supplemented with vitamin A, E and C and diabetic supplemented with ω-3 fatty acids. After four weeks the rats were anesthetized and catalase (CAT) and superoxide dismutase (SOD) activities were investigated in blood samples, liver and heart homogenates. Results: In diabetic rats, the activity levels of heart SOD (p < 0.001) and heart and liver CAT (p < 0.001) were significantly lower than in normal control rats. Supplementation with vitamins A, E and C significantly increased heart CAT (p = 0.05). No significant change was observed in diabetic rats supplemented with ω-3 fatty acids. Conclusion: Supplementation with vitamins A, E and C and ω-3 fatty acids was found to increase heart CAT activity in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.
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