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Pediatric Ocular Melanoma: A Collaborative Multicenter Study and Meta-Analysis Publisher Pubmed



Masoomian B1, 2 ; Dalvin LA3 ; Riaziesfahani H1 ; Ghassemi F1 ; Azizkhani M1 ; Mirghorbani M1 ; Khorraminejad M1 ; Sajjadi Z2 ; Kaliki S4 ; Sagoo MS5 ; Al Harby L5 ; Aljamal RT6 ; Kivela TT6 ; Giblin M7 Show All Authors
Authors
  1. Masoomian B1, 2
  2. Dalvin LA3
  3. Riaziesfahani H1
  4. Ghassemi F1
  5. Azizkhani M1
  6. Mirghorbani M1
  7. Khorraminejad M1
  8. Sajjadi Z2
  9. Kaliki S4
  10. Sagoo MS5
  11. Al Harby L5
  12. Aljamal RT6
  13. Kivela TT6
  14. Giblin M7
  15. Lim LAS7
  16. Shields CL2
Show Affiliations
Authors Affiliations
  1. 1. Ocular Oncology Service, Farabi Eye Hospital Research Center, Tehran university of medical sciences, Tehran, Iran
  2. 2. Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
  3. 3. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
  4. 4. The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Telangana, Hyderabad, India
  5. 5. Ocular Oncology Service, St Bartholomew's and Moorfields Eye Hospital, London, United Kingdom and NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  6. 6. Ocular Oncology Service, Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  7. 7. Chatswood Eye Specialists, Chatswood, Australia

Source: Journal of AAPOS Published:2023


Abstract

Purpose: To investigate clinical manifestations and prognoses in pediatric patients (≤12 years old) with ocular melanoma. Methods: This was a retrospective, multicenter cohort study with individual participant data (IPD) meta-analysis pooling available published cases, and unpublished cases from an international collaboration of seven ocular oncology centers. Results: There were 133 eyes of 133 pediatric patients with choroidal or ciliary body (n = 66 [50%]), iris (n = 33 [25%]), conjunctival (n = 26 [19%]), and eyelid (n = 8 [6%]) melanoma. Overall, the mean patient age at presentation was 7 years (median, 8; range, 1-12 years), with 63 males (49%). The mean age by tumor site was 6.50 ± 3.90, 7.44 ± 3.57, 9.12 ± 2.61, and 5.63 ± 2.38 years, for choroid/ciliary body, iris, conjunctiva, and eyelid melanoma, respectively (P = 0.001). Association with ocular melanocytosis was seen in 15%, 11%, 4%, and 0%, respectively (P = 0.01). Frequency of ocular melanoma family history did not vary by tumor site (7%, 17%, 9% and 12%, resp. [P = 0.26]). After mean follow-up of 74, 85, 50, and 105 months (P = 0.65), metastasis was seen in 12%, 9%, 19%, and 13% of choroid/ciliary body, iris, conjunctiva, and eyelid melanoma, respectively. Death was reported in 5%, 3%, 8%, and 0%, respectively, with survival analysis indicating higher mortality in choroidal/ciliary body and conjunctival melanoma patients. Conclusions: Ocular melanoma in the pediatric population is rare, with unique clinical features and outcomes. Iris melanoma accounts for about one-third of pediatric uveal melanoma cases.[Formula presented] © 2023 American Association for Pediatric Ophthalmology and Strabismus
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