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Evaluation of Antioxidant and Antibacterial Effects of the Biologically Active Metabolites From the Leaves of Ferulago Trifida Boiss Publisher



Yassa N1 ; Hadjiaghaee R2 ; Delnavazi MR1 ; Mofasseri M3 ; Ghafarzadegan R2 ; Heydari F4 ; Tavakoli S2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
  3. 3. School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
  4. 4. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran

Source: Iranian Journal of Chemistry and Chemical Engineering Published:2024


Abstract

The phytochemical analysis of methanolic fraction from leaves of Ferulago trifida Boiss. led to the identification of rutin (1), narcissin (2), heraclenol (3), xanthotoxin (4), imperatorin (5), bergapten (6), prantschimgin (7), umbelliferone (8), isogosferol (9), isopimpinellin (10), and oxyimperatorin (11). The antibacterial effect of the isolated compounds was investigated, and umbelliferone and isogosferol showed a moderate antibacterial effect on S. epidermidis (IZ: 15 mm, MIC: 500 μg/mL) and S. dysenteriae (IZ: 16 mm, MIC: 500 μg/mL), respectively, compared to gentamicin and rifampin. The antioxidant capacity of the methanolic and chloroform extracts elucidated from leaves was examined by DPPH and FRAP tests. The results showed weak antioxidant potency in the DPPH method for methanol (IC50: 81.1 µg/mL) and chloroform fractions (IC50: 125.2 µg/mL) compared to BHT (IC50: 19.2 µg/mL) as a positive control. The methanol extract (67.1 ± 2.9 mmol FSE/100 g) and chloroform extract (77.4 ± 4.1 mmol FSE/100 g) also showed weak antioxidant activity according to the FRAP compared to the BHT (267.2 ± 4.2 mmol FSE/100 g). © 2024, Iranian Institute of Research and Development in Chemical Industries. All rights reserved.
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