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Trachyspermum Copticum Essential Oil Incorporated Niosome for Cancer Treatment Publisher



Trinh LH1 ; Takzare A2 ; Ghafoor DD3 ; Siddiqi AF4 ; Ravali S5 ; Shalbaf M6 ; Bakhtiar M7
Authors
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Authors Affiliations
  1. 1. Hanoi Medical University, Hanoi Medical University Hospital, Hanoi, Viet Nam
  2. 2. Anaesthesiology Department, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Laboratory Science, College of Science, Komar University of Science and Technology, Kurdistan, Iraq
  4. 4. UCP Business School University of Central Punjab Lahore Pakistan, Pakistan
  5. 5. Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Chennai, India
  6. 6. South Tehran Branch, Islamic Azad University, Tehran, Iran
  7. 7. Marquette University, Milwaukee, WI, United States

Source: Journal of Drug Delivery Science and Technology Published:2019


Abstract

The Trachyspermum copticum essential oil (TCEO) has been incorporated into niosomes (NIO-TCEO). The chemical composition of the TCEO has been evaluated using Gas chromatography mass spectrometry (GC-MS) and the antioxidant activity of the TCEO has been characterized by radical scavenging capacity (RSC). The niosomes have been characterized with respect to their size, zeta potential, morphology, encapsulation efficiency, in vitro release, and cell toxicity against hepatocellular carcinoma cell line (HepG2). The interaction of the TCEO with niosomes has been studied using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Our study has shown an excellent antioxidant activity of the essential oil with IC50 of 18.32 ± 3.6 μg/ml. The size of the niosomes has been around 151.06 ± 5.3 nm and the TCEO entrapment efficiency has been 87.41 ± 5.97%. Our results have demonstrated that niosomes loaded with TCEO have a potential application for cancer therapy. © 2019 Elsevier B.V.
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