Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Global Prevalence of Mild Cognitive Impairment in Geriatric Population With Emphasis on Influential Factors: A Systematic Review and Meta-Analysis Publisher Pubmed



Salari N1 ; Lotfi F2 ; Abdolmaleki A3 ; Heidarian P2 ; Rasoulpoor S4 ; Fazeli J5 ; Najafi H6 ; Mohammadi M7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Operating Room, Nahavand School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Department of Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Nursing, Urmia, Iran
  5. 5. Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Geriatric Health, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran

Source: BMC Geriatrics Published:2025


Abstract

Background: Mild cognitive impairment (MCI) is a common disorder among the geriatric population (GP). MCI induces adverse effects on life quality by disrupting of natural aging process, daily activities, and memory. This systematic review and meta-analysis study aimed to investigate the global prevalence of MCI in GP with an emphasis on associated influential factors. Methods: Electronic databases of PubMed, Scopus, WoS, Embase, ScienceDirect, and Google Scholar were systematically searched (by November 2024) using the MeSH-based keywords. Collected references were imported into the Citation Management Software of EndNote (v.8) for duplicate detection. Paper screenings and quality assessments were applied based on the inclusion and exclusion criteria. Then, eligible papers were gathered and data analysis was performed using CMA software (v.2). Results: In the review of 51 eligible studies (n = 287,689 elderly individuals), the global prevalence of mild cognitive impairment in geriatric population was found 23.7% (95%CI:18.6–29.6). According to the meta-regression analysis, following the increase in sample size and year of paper publication, the mild cognitive impairment index decreased and increased, respectively. Besides, age, educational level, and depression status were considered the most critical influential factors of mild cognitive impairment in geriatric population. Conclusion: According to the relatively high prevalence of mild cognitive impairment in geriatric population, determination of proper health strategies seems necessary for diagnosis and treatment of mild cognitive impairment along with awareness and management of associated consequences in geriatric population. Clinical trial number: Not applicable. © The Author(s) 2025.
Related Docs
1. Prevalence and Associated Factors of Mild Cognitive Impairment Among Middle-Aged and Older Adults: Results of the First Phase of Ardakan Cohort Study on Aging, Health Science Reports (2024)
2. Altered Brain Connectivity in Mild Cognitive Impairment Is Linked to Elevated Tau and Phosphorylated Tau, But Not to Gap-43 and Amyloid-Β Measurements: A Resting-State Fmri Study, Molecular Brain (2024)