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Association of Interleukin-17A Rs2275913 Polymorphism With Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study Publisher



Keshavarz Motamed A1 ; Zarei Z2 ; Mirfakhraee H3, 4 ; Shariatinia F5 ; Akbari M6 ; Ziagham S7 ; Igder S8 ; Zarei N8
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran, Iran
  4. 4. Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran
  5. 5. Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran
  6. 6. Department of Midwifery, Shushtar Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. Department of Gynecology and Obstetrics, Qazvin University of Medical Sciences, Qazvin, Iran

Source: International Journal of Fertility and Sterility Published:2024


Abstract

Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the 20 weeks of pregnancy. The present study was undertaken to investigate association of Interleukin-17A (IL-17A) rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed, Embase, and Scopus) and extracted studies investigating the association of IL-17A rs2275913 polymorphism with RM using the appropriate keywords. The collected data were analyzed with the random-effects model and STATA (version 14). A total of five studies met the eligibility criteria, and total sample size was 998 subjects. Mean age of the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significant relationship of the IL-17A rs2275913 AA genotype [odds ratio (OR)=1.68; 95% confidence interval (CI)=1.16-2.43; I2=19; P=0.294) with RM. There was no statistically significant correlation between IL-17A rs2275913 GG genotype (OR=1.04; 95% CI=0.64-1.7; I2=59.5; P=0.042) and GA genotype (OR=0.85; 95% CI=0.65-1.12; I2=19.1; P=0.293) with RM. Our findings revealed that the IL-17A rs2275913 polymorphism is associated with RM, and the AA genotype of this polymorphism increased possibility of being involved in RM. © 2023, Royan Institute (ACECR). All rights reserved.
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