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Cytotoxicity of Two Experimental Epoxy Resin-Based Sealers Publisher



Ashraf H1 ; Najafi F2 ; Heidari S3 ; Yadegary Z3 ; Zadsirjan S1
Authors
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Authors Affiliations
  1. 1. Department of Endodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Resin and Adhesives, Institute for Color Science and Technology, Tehran, Iran
  3. 3. Department of Dental Biomaterials, Dental School, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Endodontic Journal Published:2018


Abstract

Introduction: Many endodontic sealers are available, but search for the ideal sealer continues. This study aimed to assess the cytotoxicity of two experimental endodontic sealers in comparison with AH-26 resin sealer. Methods and Materials: This in vitro study was conducted on conventional and experimental root canal sealers: AH-26, an epoxy resin experimental sealer A (ES-A) composed of calcium tungstate, zirconium oxide, aerosil, bismuth oxide, titanium oxide, hexamine and an epoxy resin and experimental sealer B (ES-B) with compositions similar to ES-A except for the presence of imidazoline as a catalyst. The experimental sealers containing nano-particles were mixed with 37.5% of an epoxy resin. The extraction of five samples of each experimental sealer (A, B) and AH-26 sealer were subjected to MTT assay in the form of set and fresh at 1, 24 and 72 h with 1, 10, 100% dilution according to the International Standard ISO:10993-2012. Data were analyzed using the one-way ANOVA. Results: The set ES-A had the least cytotoxicity from the first hour but the cytotoxicity of ES-B and AH-26 extraction decreased over time. In fresh form, except for 100% concentration, ESA showed the least cytotoxicity compared to the other two sealers. Conclusion: All three sealers had high cytotoxicity in 100% concentration but had low cytotoxicity in 10% and 1% concentrations. © 2018, Iranian Association of Endodontics. All rights reserved.