The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage

The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage Publisher

Mosaferi E¹ ; Gharamaleki NA¹ ; Farzadi L² ; Majidi J¹ ; Babaloo Z¹ ; Kazemi T¹ ; Ramezani M³ ; Tabatabaei M⁴ ; Ahmadi H⁵ ; Maleki LA¹ ; Baradaran B¹

Show Affiliations

1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Women Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3. Department of Biochemistry, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
4. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Advanced Pharmaceutical Bulletin Published:2019

Abstract

Purpose: Although it has been frequently confirmed that HLA-G plays an important role in the reproduction and pregnancy, the pattern of HLA-G gene and its protein expression are rarely addressed in studies. Therefore we conducted this study in regard to evaluate the HLA-G gene and its protein expression in the women's placenta with recurrent miscarriage. Methods: Placental samples were obtained from the women who were admitted for delivery or abortion in Al Zahra and Taleghani hospitals, Tabriz, Iran. HLA-G gene expression was determined by real-time polymerase chain reaction (PCR) and HLA-G protein expression was assessed by western blotting and immunofluorescence staining in the tissue samples. Results: The results showed a significant decrease in the expression of gene and proteins of HLA-G in the women with recurrent miscarriage compared to the control placental tissues. Conclusion: According to the obtained results, it was concluded that the decrement of HLA-G gene and protein expressions are associated with recurrent miscarriage. Since there are conflicting results from other studies, it is suggested to conduct a more comprehensive similar study with greater sample size. © 2019 The Author (s).

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Amirhasan Zarnani (1)

Style	Citing Format
MLA	Mosaferi E, et al.. "The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage." Advanced Pharmaceutical Bulletin, vol. 9, no. 1, 2019, pp. 70-75.
APA	Mosaferi E, Gharamaleki NA, Farzadi L, Majidi J, Babaloo Z, Kazemi T, Ramezani M, Tabatabaei M, Ahmadi H, Maleki LA, Baradaran B (2019). The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage. Advanced Pharmaceutical Bulletin, 9(1), 70-75.
Chicago	Mosaferi E, Gharamaleki NA, Farzadi L, Majidi J, Babaloo Z, Kazemi T, Ramezani M, et al.. "The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage." Advanced Pharmaceutical Bulletin 9, no. 1 (2019): 70-75.
Harvard	Mosaferi E et al. (2019) 'The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage', Advanced Pharmaceutical Bulletin, 9(1), pp. 70-75.
Vancouver	Mosaferi E, Gharamaleki NA, Farzadi L, Majidi J, Babaloo Z, Kazemi T, et al.. The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage. Advanced Pharmaceutical Bulletin. 2019;9(1):70-75.
BibTex	@article{ author = {Mosaferi E and Gharamaleki NA and Farzadi L and Majidi J and Babaloo Z and Kazemi T and Ramezani M and Tabatabaei M and Ahmadi H and Maleki LA and Baradaran B}, title = {The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage}, journal = {Advanced Pharmaceutical Bulletin}, volume = {9}, number = {1}, pages = {70-75}, year = {2019} }
RIS	TY - JOUR AU - Mosaferi E AU - Gharamaleki NA AU - Farzadi L AU - Majidi J AU - Babaloo Z AU - Kazemi T AU - Ramezani M AU - Tabatabaei M AU - Ahmadi H AU - Maleki LA AU - Baradaran B TI - The Study of Hla-G Gene and Protein Expression in Patients With Recurrent Miscarriage JO - Advanced Pharmaceutical Bulletin VL - 9 IS - 1 SP - 70 EP - 75 PY - 2019 ER -

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