Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach

Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach Publisher Pubmed

Iman M¹ ; Shafaroodi H² ; Davood A³ ; Abedini M³ ; Pishva P² ; Taherkhani M² ; Dehpour AR⁴ ; Shafiee A⁵

Show Affiliations

1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, IAUPS, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, IAUPS, Tehran, Iran
4. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Pharmaceutical Design Published:2016

Abstract

Phthalimide and hydrazine pharmacophores have been demonstrated to be inhibitors of cyclooxygenases (COX) and lipoxygenases (LOX) and to possess a marked analgesic and anti-inflammatory activity. A new group of hybrid analogs of phthalimide and hydrazine (2-(arylmethylideneamino) isoindolines), possessing a variety of substituents (OMe, OH, NO2, Cl, and F) at different positions of the aryl ring, were synthesized and their analgesic and anti-inflammatory effects were evaluated. In vivo screening showed that all the analogs possessed analgesic and anti-inflammatory activity and compounds 10g, 10h and 10e were the most potent as analgesic and compounds 10b, 10c and 10i were the most potent as anti-inflammatory agents. © 2016 Bentham Science Publishers.

Style	Citing Format
MLA	Iman M, et al.. "Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach." Current Pharmaceutical Design, vol. 22, no. 37, 2016, pp. 5760-5766.
APA	Iman M, Shafaroodi H, Davood A, Abedini M, Pishva P, Taherkhani M, Dehpour AR, Shafiee A (2016). Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach. Current Pharmaceutical Design, 22(37), 5760-5766.
Chicago	Iman M, Shafaroodi H, Davood A, Abedini M, Pishva P, Taherkhani M, Dehpour AR, Shafiee A. "Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach." Current Pharmaceutical Design 22, no. 37 (2016): 5760-5766.
Harvard	Iman M et al. (2016) 'Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach', Current Pharmaceutical Design, 22(37), pp. 5760-5766.
Vancouver	Iman M, Shafaroodi H, Davood A, Abedini M, Pishva P, Taherkhani M, et al.. Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach. Current Pharmaceutical Design. 2016;22(37):5760-5766.
BibTex	@article{ author = {Iman M and Shafaroodi H and Davood A and Abedini M and Pishva P and Taherkhani M and Dehpour AR and Shafiee A}, title = {Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach}, journal = {Current Pharmaceutical Design}, volume = {22}, number = {37}, pages = {5760-5766}, year = {2016} }
RIS	TY - JOUR AU - Iman M AU - Shafaroodi H AU - Davood A AU - Abedini M AU - Pishva P AU - Taherkhani M AU - Dehpour AR AU - Shafiee A TI - Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach JO - Current Pharmaceutical Design VL - 22 IS - 37 SP - 5760 EP - 5766 PY - 2016 ER -

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