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Prevalence and Associated Factors of Ecg Abnormality Patterns Indicative of Cardiac Channelopathies Among Adult General Population of Tehran, Iran: A Report From the Tehran Cohort Study (Tecs) Publisher Pubmed



Ahmadirenani S1, 2 ; Soltani D1 ; Farshbafnadi M3 ; Shafiee A2 ; Jalali A1, 4 ; Mohammadi M2 ; Golestanian S5 ; Kamalian E6 ; Alaeddini F2 ; Saadat S7 ; Sadeghian S2 ; Mansoury B8 ; Boroumand M2 ; Karimi A2 Show All Authors
Authors
  1. Ahmadirenani S1, 2
  2. Soltani D1
  3. Farshbafnadi M3
  4. Shafiee A2
  5. Jalali A1, 4
  6. Mohammadi M2
  7. Golestanian S5
  8. Kamalian E6
  9. Alaeddini F2
  10. Saadat S7
  11. Sadeghian S2
  12. Mansoury B8
  13. Boroumand M2
  14. Karimi A2
  15. Masoudkabir F1
  16. Vasheghanifarahani A1
Show Affiliations
Authors Affiliations
  1. 1. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran
  6. 6. Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
  7. 7. Department of Emergency Medicine, University of California, Irvine, Irvine, CA, United States
  8. 8. Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

Source: BMC Cardiovascular Disorders Published:2024


Abstract

Background: The characteristics of electrocardiogram (ECG) abnormalities related to cardiac channelopathies potentially linked to sudden cardiac death (SCD) are not widely recognized in Iran. We examined the prevalence of such ECG patterns and their related factors among adult residents of Tehran, Iran. Methods: The clinical characteristics and 12-lead ECGs of Tehran Cohort Study participants were examined. Long QT intervals, short QT intervals, Brugada syndrome (BrS) patterns, and early repolarization (ER) were evaluated using computer-based assessment software validated by cardiologists. Logistic regression models were employed to identify the factors associated with the prevalence of different ECG patterns. Results: Out of 7678 available ECGs, 7350 were included in this analysis. Long QT interval, ER pattern, BrS patterns, and short QT interval were found in 3.08%, 1.43%, 0.31%, and 0.03% of participants, respectively. The prevalence of long QT interval increased with age, opium consumption, and presence of hypertension. Younger age, lower body mass index (BMI), alcohol use and male sex were independently linked to an elevated prevalence of ER pattern. Most individuals with BrS patterns were men (95%) and had lower BMI, high- and low-density lipoprotein, and total cholesterol compared to those without the BrS pattern. At a mean follow-up of 30.2 ± 5.5 months, all-cause mortality in the group exhibiting abnormal ECG patterns (6.3%) was approximately twice as high as that in the group without such patterns (2.96%). Conclusion: Abnormal ECG patterns corresponding to channelopathies were relatively rare among adult residents of the Tehran population, and their prevalence was influenced by various factors. Clinical trial number: Not applicable. © The Author(s) 2024.
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