Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study

Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study Publisher Pubmed

Nobakht BF^{1, 2} ; Aliannejad R³ ; Rezaeitavirani M¹ ; Arefi Oskouie A² ; Naseri MT⁴ ; Parastar H⁵ ; Aliakbarzadeh G⁶ ; Fathi F⁵ ; Taheri S⁷

Show Affiliations

1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciencesc, Tehran, Iran
2. Faculty of Paramedical Sciences, Department of Basic Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Pulmonary Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Chemistry, Faculty of Paramedical Sciences, Tarbiat Modares University, Tehran, Iran
5. Department of Chemistry, Sharif University of Technology, Tehran, Iran
6. Department of Chemistry, Faculty of Science, University of Tehran, Tehran, Iran
7. Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran

Source: Biomarkers Published:2016

Abstract

Sulfur mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and healthy controls are observed are related to lipid metabolism, ketogenesis, tricarboxylic acid (TCA) cycle and amino acid metabolism. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Nobakht BF, et al.. "Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study." Biomarkers, vol. 21, no. 6, 2016, pp. 479-489.
APA	Nobakht BF, Aliannejad R, Rezaeitavirani M, Arefi Oskouie A, Naseri MT, Parastar H, Aliakbarzadeh G, Fathi F, Taheri S (2016). Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study. Biomarkers, 21(6), 479-489.
Chicago	Nobakht BF, Aliannejad R, Rezaeitavirani M, Arefi Oskouie A, Naseri MT, Parastar H, Aliakbarzadeh G, Fathi F, Taheri S. "Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study." Biomarkers 21, no. 6 (2016): 479-489.
Harvard	Nobakht BF et al. (2016) 'Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study', Biomarkers, 21(6), pp. 479-489.
Vancouver	Nobakht BF, Aliannejad R, Rezaeitavirani M, Arefi Oskouie A, Naseri MT, Parastar H, et al.. Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study. Biomarkers. 2016;21(6):479-489.
BibTex	@article{ author = {Nobakht BF and Aliannejad R and Rezaeitavirani M and Arefi Oskouie A and Naseri MT and Parastar H and Aliakbarzadeh G and Fathi F and Taheri S}, title = {Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study}, journal = {Biomarkers}, volume = {21}, number = {6}, pages = {479-489}, year = {2016} }
RIS	TY - JOUR AU - Nobakht BF AU - Aliannejad R AU - Rezaeitavirani M AU - Arefi Oskouie A AU - Naseri MT AU - Parastar H AU - Aliakbarzadeh G AU - Fathi F AU - Taheri S TI - Nmr- and Gc/Ms-Based Metabolomics of Sulfur Mustard Exposed Individuals: A Pilot Study JO - Biomarkers VL - 21 IS - 6 SP - 479 EP - 489 PY - 2016 ER -

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