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Brain-Derived Neurotrophic Factor (Bdnf) As a Potential Marker of Endometriosis: A Systematic Review and Meta-Analysis Publisher Pubmed



Jafarabady K1 ; Shafiee A1, 2 ; Bahri RA3 ; Mohammadi I4 ; Amini M1 ; Rajai S4 ; Akbarzadeh D4 ; Abhari FS2 ; Movahed E8 ; Parvari S5 ; Bakhtiyari M6, 7
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Department of Psychiatry and Mental Health, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Anatomical Sciences, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Department of Community Medicine and Epidemiology, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Dental Reaserch Center, Faculty of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran

Source: BMC Women's Health Published:2024


Abstract

Background: The existing literature on the association between BDNF protein levels and endometriosis presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and evaluate the possible relationship between BDNF protein levels and endometriosis. Methods: Electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) were used to conduct a comprehensive literature search from inception to June 2023. The search strategy included relevant keywords and medical subject headings (MeSH) terms related to BDNF, endometriosis, and protein levels. A random-effects model was used for the meta-analysis, and to explore heterogeneity subgroup analyses were performed. funnel plots and statistical tests were used for assessing the publication bias. Results: A total of 12 studies were included. The pooled standardized mean difference (SMD) of BDNF levels between women with endometriosis and controls was 0.87 (95% confidence interval [CI] 0.34 to 1.39, p = 0.001; I2 = 93%). The results showed that blood levels of BDNF are significantly higher in endometriosis patients (SMD: 1.13 95% CI 0.54 to 1.73, p = 0.0002; I2 = 93%). No significant publication bias was observed based on the results of Egger’s regression test ((p = 0.15). Conclusion: This study revealed a significant difference between patients diagnosed with endometriosis and healthy control in the level of BDNF. The results indicate that women with endometriosis have higher levels of BDNF. Further studies are needed to be undertaken to investigate the role of BDNF in endometriosis pathophysiology and the diagnostic value of BDNF in endometriosis. © 2024, The Author(s).
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