Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Micrornas in Breast Cancer: Roles, Functions, and Mechanism of Actions Publisher Pubmed



Abolghasemi M1, 2 ; Tehrani SS3, 4 ; Yousefi T1, 2 ; Karimian A1, 2 ; Mahmoodpoor A5 ; Ghamari A5 ; Jadidiniaragh F6 ; Yousefi M6 ; Kafil HS13 ; Bastami M6 ; Edalati M14 ; Eyvazi S7 ; Naghizadeh M3, 4 ; Targhazeh N8 Show All Authors
Authors
  1. Abolghasemi M1, 2
  2. Tehrani SS3, 4
  3. Yousefi T1, 2
  4. Karimian A1, 2
  5. Mahmoodpoor A5
  6. Ghamari A5
  7. Jadidiniaragh F6
  8. Yousefi M6
  9. Kafil HS13
  10. Bastami M6
  11. Edalati M14
  12. Eyvazi S7
  13. Naghizadeh M3, 4
  14. Targhazeh N8
  15. Yousefi B9
  16. Safa A10
  17. Majidinia M11
  18. Rameshknia V9, 12
Show Affiliations
Authors Affiliations
  1. 1. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Iran
  2. 2. Student Research Committee, Babol University of medical sciences, Babol, Iran
  3. 3. Departmant of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Anesthesiology Research Team, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Student Research Committee, Babol University Of Medical Sciences, Babol, Iran
  9. 9. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam
  11. 11. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
  12. 12. Faculty of Medicine, Islamic Azad University, Tabriz, Iran
  13. 13. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  14. 14. Department of Laboratory Sciences, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Cellular Physiology Published:2020


Abstract

Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor-κ B, phosphoinositide-3-kinase/Akt, and extracellular-signal-regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer. © 2019 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. The Role of Inflammation and Its Related Micrornas in Breast Cancer: A Narrative Review, Journal of Cellular Physiology (2019)
2. Investigation of Mir-133A, Mir-637 and Mir-944 Genes Expression and Their Relationship With Pi3k/Akt Signaling in Women With Breast Cancer, Journal of Cancer Research and Clinical Oncology (2023)
3. A Comprehensive Review on Oncogenic Mirnas in Breast Cancer, Journal of Genetics (2021)
4. The Role of Oncomirs in the Pathogenesis and Treatment of Breast Cancer, Biomedicine and Pharmacotherapy (2016)
5. Critical Roles of Long Noncoding Rnas in Breast Cancer, Journal of Cellular Physiology (2020)
6. Competing Endogenous Rna (Cerna) Cross Talk and Language in Cerna Regulatory Networks: A New Look at Hallmarks of Breast Cancer, Journal of Cellular Physiology (2019)
7. Recent Advances on Immune Targeted Therapy of Colorectal Cancer Using Bi-Specific Antibodies and Therapeutic Vaccines, Biological Procedures Online (2021)
8. Plasma Mir-21, Mir-155, Mir-10B, and Let-7A As the Potential Biomarkers for the Monitoring of Breast Cancer Patients, Scientific Reports (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Mahsa Mohamad Amoli (2)
Other Related Docs
9. In-Silico and In-Vitro Evidence Suggest Linc01405 As a Sponge for Mir-29B and Mir-497-5P, and a Potential Regulator of Wnt, Pi3k, and Tgfb Signaling Pathways in Breast Carcinoma, Cancer Reports (2024)
10. Immune Therapy of Melanoma: Overview of Therapeutic Vaccines, Journal of Cellular Physiology (2019)
11. Emerging Roles of Exosomal Mirnas in Breast Cancer Drug Resistance, IUBMB Life (2019)
12. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
13. Synergistic Effect of Microrna and Albumin-Bound Nanoparticles for Inhibition of Glioblastoma Cancer Cell Proliferation, Brazilian Journal of Pharmaceutical Sciences (2020)
14. Layered Double Hydroxide Nanoparticles As an Appealing Nanoparticle in Gene/Plasmid and Drug Delivery System in C2c12 Myoblast Cells, Artificial Cells# Nanomedicine and Biotechnology (2019)
15. How Micrornas Affect the Pd-L1 and Its Synthetic Pathway in Cancer, International Immunopharmacology (2020)
16. Inflammation Related Mirnas As an Important Player Between Obesity and Cancers, Journal of Diabetes and Metabolic Disorders (2019)
17. Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis, Frontiers in Oncology (2023)
18. Expression Analysis of Selected Mir-206 Targets From the Transforming Growth Factor-Β Signaling Pathway in Breast Cancer, Journal of Cellular Biochemistry (2019)
19. Diagnostic, Prognostic, and Therapeutic Significance of Mir-139-5P in Cancers, Life Sciences (2020)
20. Microrna-203 Reinforces Stemness Properties in Melanoma and Augments Tumorigenesis in Vivo, Journal of Cellular Physiology (2019)
21. Prognostic and Diagnostic Values of Non-Coding Rnas As Biomarkers for Breast Cancer: An Umbrella Review and Pan-Cancer Analysis, Frontiers in Molecular Biosciences (2023)
22. The Power of Precise Bioinformatics Prediction of Mirna:Mrna Interactions:Mir-4699 As a Potential Inducer of Wnt Signaling Pathway, Journal of Cellular Biochemistry (2018)
23. Microrna-Related Single-Nucleotide Polymorphisms and Breast Cancer, Journal of Cellular Physiology (2021)
24. Lung Cancer and Mirnas: A Possible Remedy for Anti-Metastatic, Therapeutic and Diagnostic Applications, Expert Review of Respiratory Medicine (2017)
25. Overview of Cd24 As a New Molecular Marker in Ovarian Cancer, Journal of Cellular Physiology (2019)
26. Micrornas Signatures, Bioinformatics Analysis of Mirnas, Mirna Mimics and Antagonists, and Mirna Therapeutics in Osteosarcoma, Cancer Cell International (2020)
27. The Role of Noncoding Rnas in Pituitary Adenoma, Epigenomics (2021)
28. Critical Review of Epstein–Barr Virus Micrornas Relation With Ebv-Associated Gastric Cancer, Journal of Cellular Physiology (2021)
29. A Novel Panel of Blood-Based Micrornas Capable of Discrimination Between Benign Breast Disease and Breast Cancer at Early Stages, RNA Biology (2021)
30. Expression of Mirnas Targeting Mtor and S6k1 Genes of Mtor Signaling Pathway Including Mir-96, Mir-557, and Mir-3182 in Triple-Negative Breast Cancer, Applied Biochemistry and Biotechnology (2018)
31. Increased Levels of Serum and Tissue Mir-107 in Human Gastric Cancer: Correlation With Tumor Hypoxia, Cancer Biomarkers (2015)
32. Micrornas-Based Imaging Techniques in Cancer Diagnosis and Therapy, Journal of Cellular Biochemistry (2017)
33. Long Non-Coding Rnas (Lncrnas); Roles in Tumorigenesis and Potentials As Biomarkers in Cancer Diagnosis, Experimental Cell Research (2022)
34. Transient Induction of Cdk9 in the Early Stage of Differentiation Is Critical for Myogenesis, Journal of Cellular Biochemistry (2019)
35. Concomitant Overexpression of Mir-182-5P and Mir-182-3P Raises the Possibility of Il-17–Producing Treg Formation in Breast Cancer by Targeting Cd3d, Itk, Foxo1, and Nfats: A Meta-Analysis and Experimental Study, Cancer Science (2021)