Coronavirus: Pure Infectious Disease or Genetic Predisposition Publisher Pubmed



Darbeheshti F^{1, 2} ; Abolhassani H^{3, 4, 5} ; Bashashati M^{6, 7} ; Ghavami S^{8, 9} ; Shahkarami S^{2, 10} ; Zoghi S^{4, 11} ; Gupta S¹² ; Orange JS¹³ ; Ochs HD^{14, 15} ; Rezaei N^{4, 16, 17, 18} Show Affiliations
Source: Advances in Experimental Medicine and Biology Published:2021

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease (COVID-19), is the seventh pathogenic coronavirus recently discovered in December 2019 in Wuhan, China. To date, our knowledge about its effect on the human host remains limited. It is well known that host genetic factors account for the individual differences in the susceptibility to infectious diseases. The genetic susceptibility factors to COVID-19 and its severity are associated with several unanswered questions. However, the experience gained from an earlier strain of coronavirus, SARS-CoV-1, which shows 78% genetic similarity to SARS-CoV-2 and uses the same receptor to bind to host cells, could provide some clues. It, therefore, seems possible to assemble new evidence in order to solve a potential genetic predisposition puzzle for COVID-19. In this chapter, the puzzle pieces, including virus entry receptors, immune response, and inflammation-related genes, as well as the probable genetic predisposition models to COVID-19, are discussed. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.