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Synthesis and Characterization of Carboxymethyl Chitosan/Polyvinyl Alcohol Containing Zinc Oxide Nanoparticles As Hydrogel Wound Dressing Publisher



Bakhtiari K1, 2 ; Kashanian S1, 3 ; Mohamadinooripoor R1 ; Rashidi K4 ; Sajadimajd S5 ; Omidfar K2, 6
Authors
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Authors Affiliations
  1. 1. Faculty of Chemistry, Razi University, Kermanshah, Iran
  2. 2. Biosensor research center, Endocrinology and Metabolism Molecular-Cellular Science Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Nanobiotechnology, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran
  4. 4. Research Center of Oils and Fats, Kermanshah University of Medical Science, Kermanshah, Iran
  5. 5. Department of Biology, School of Sciences, Razi University, Kermanshah, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Fibers and Polymers Published:2024


Abstract

In the biomedical field, hydrogels are extensively utilized due to their ability to provide mechanical support and create a moist environment for wounds. In this study, nanocomposite hydrogels containing carboxymethyl chitosan (CsMe), polyvinyl alcohol (PVA), and zinc oxide nanoparticles (ZnO-NPs) in different weight ratios (0, 0.5, 0.8, and 1.2%) were prepared for wound healing. The prepared hydrogels were analyzed using Fourier transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy (FE-SEM), and X-ray diffraction (XRD). Additionally, the mechanical properties, swelling ratio, MTT assay, antibacterial efficacy, and in vivo wound healing were assessed. MTT assays indicated no toxicity after incorporating ZnO-NPs into the hydrogel, and the maximum antibacterial efficiencies of CsMe/PVA/ZnO-NPs (0.5%) hydrogels against E. coli and S. aureus were 91.85 ± 1.2% and 52.7 ± 0.84%, respectively. In vivo studies demonstrated that the hydrogel containing 0.5% ZnO-NPs significantly accelerated wound healing, with 96 ± 2.41% wound closure after 14 days, compared to 83.5 ± 6.76% for the group treated with commercial ZnO ointment. The results suggest that ZnO-NPs in hydrogels enhance antibacterial activity and promote better wound healing than traditional ZnO ointments, offering a promising material for advanced wound care applications. © The Author(s), under exclusive licence to the Korean Fiber Society 2024.