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Base-Free Green Synthesis of Copper(Ii) Oxide Nanoparticles Using Highly Cross-Linked Poly(Curcumin) Nanospheres: Synergistically Improved Antimicrobial Activity Publisher



Farkhonde Masoule S1, 2 ; Pourhajibagher M3 ; Safari J2 ; Khoobi M1, 4
Authors
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Authors Affiliations
  1. 1. The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Laboratory of Organic Compound Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, P.O. Box 87317-51167, Kashan, Iran
  3. 3. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmaceutical Biomaterials, Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Research on Chemical Intermediates Published:2019


Abstract

Antimicrobial activity of metal containing formulas has drawn attention and been widely investigated. In this research, CuO/hc-pCUR nanocomposite composed of copper(II) oxide nanoparticles (CuO NPs) and highly cross-linked poly(curcumin) nanospheres (hc-pCUR-NS) was easily prepared via in situ base-free precipitation and evaluated as an antimicrobial agent. Copper was bound to hc-pCUR-NS using the ability of the β-diketone moiety of CUR to chelate metal ions. CuO/hc-pCUR nanocomposite was fully characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, ultraviolet–visible spectrometry, X-ray diffraction, Fourier transform infrared spectroscopy, and zeta potential analysis. The size of the negatively charged spherical nanocomposites was about 246 nm bearing small spherical CuO NPs (~ 34 nm). Comparative antimicrobial assays were performed against both Gram-positive (Enterococcus faecalis) and Gram-negative (Pseudomonas aeruginosa) bacteria. Interestingly, hc-pCUR-NS showed more antimicrobial activity than free CUR against both Gram-positive and Gram-negative bacteria and addition of copper nanoparticles significantly improved the inhibitory effect of hc-pCUR-NS. All samples showed more antimicrobial activity against Gram positives compared with Gram negatives. These noticeable outcomes encouraged us to introduce CuO/hc-pCUR nanocomposites as promising antimicrobial agents for further study. © 2019, Springer Nature B.V.