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Analysis of Single Nucleotide Polymorphisms in Hla-Dra, Il2ra, and Hmgb1 Genes in Multiple Sclerosis Publisher



Asouri M1, 2 ; Rokni HA3 ; Sahraian MA4 ; Fattahi S2 ; Motamed N5 ; Doosti R4 ; Rahimi H1 ; Lotfi M2 ; Moslemi A6 ; Karimpoor M1 ; Mahboudi F1 ; Akhavanniaki H7, 8
Authors
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Authors Affiliations
  1. 1. Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  2. 2. North Research Center, Pasteur Institute of Iran, Amol, Iran
  3. 3. Systems Biology and Health Data Analytics Lab, the Graduate School of Biomedical Engineering, UNSW, Sydney, 2052, NSW, Australia
  4. 4. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  6. 6. Department of Biostatistics, Faculty of Medical Sciences, Arak University of Medical Sciences, Arak, Iran
  7. 7. Zoonoses Research Center, North Research Center, Pasteur Institute of Iran, Amol, Iran
  8. 8. Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Source: Reports of Biochemistry and Molecular Biology Published:2020


Abstract

Background: Multiple sclerosis (MS) is a common demyelinating neurodegenerative disorder with significant heritability. Previous studies have associated genetic variants in human leukocyte antigen (HLA) complex, IL2RA, and HMGB1 genes with the pathophysiology of MS. Methods: In order to investigate the gene association in the Iranian population, we performed a genotyping study of 36 variants in the mentioned genes using Sanger sequencing in 102 MS patients and 113 healthy controls. Results: Our results identified significant associations as well as significant allele frequency differences in some of the studied single-nucleotide polymorphisms including rs4935356, rs3177928, and rs7197 from HLA-DRA gene, and rs12722489 and rs12722490 variants from IL2RA gene (p< 0.05). Moreover, the strong linkage disequilibrium of two common haplotypes was estimated from the HLA-DRA gene. Conclusions: This association study may suggest the role of these polymorphisms in the genetic susceptibility of MS in the Iranian population and would facilitate the recognition of causative variants in this disease. © 2020. All Rights Reserved.