Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations

Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations Publisher Pubmed

Pourmand SMH ; Halimi M ; Alaeddini A ; Akbari M ; Noori M ; Mojtabavi S ; Faramarzi MA ; Mohammadikhanaposhti M ; Larijani B ; Dadgar A ; Mahdavic M

Source: Bioorganic Chemistry Published:2025

Abstract

Due to the presence of pyridine, coumarin, and chroman heterocycles in the potent α-glucosidase inhibitors, here, these heterocycles were fused together and 14 derivatives 8a-n were synthesized of this fused structure. After synthesis, new chroman-pyridine-coumarin derivatives 8a-n were evaluated against yeast form of α-glucosidase and after determination of the most potent compound, kinetic study was performed on it. In vitro enzymatic inhibition assay showed that all the new compounds 8a-n were more potent than used standard inhibitor (acarbose) and the most potent compounds, were compounds 8e and 8d with inhibitory activities around 20.7 folds more than standard inhibitor. In vitro kinetic study demonstrated that these compounds, like standard inhibitor, were competitive inhibitors. In silico docking and dynamics studies on the most potent compounds showed that these compounds formed stable complexes with the active site of α-glucosidase. © 2025 Elsevier B.V., All rights reserved.

Style	Citing Format
MLA	Pourmand SMH, et al.. "Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations." Bioorganic Chemistry, vol. 166, no. , 2025, pp. -.
APA	Pourmand SMH, Halimi M, Alaeddini A, Akbari M, Noori M, Mojtabavi S, Faramarzi MA, Mohammadikhanaposhti M, Larijani B, Dadgar A, Mahdavic M (2025). Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations. Bioorganic Chemistry, 166(), -.
Chicago	Pourmand SMH, Halimi M, Alaeddini A, Akbari M, Noori M, Mojtabavi S, Faramarzi MA, et al.. "Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations." Bioorganic Chemistry 166, no. (2025): -.
Harvard	Pourmand SMH et al. (2025) 'Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations', Bioorganic Chemistry, 166(), pp. -.
Vancouver	Pourmand SMH, Halimi M, Alaeddini A, Akbari M, Noori M, Mojtabavi S, et al.. Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations. Bioorganic Chemistry. 2025;166():-.
BibTex	@article{ author = {Pourmand SMH and Halimi M and Alaeddini A and Akbari M and Noori M and Mojtabavi S and Faramarzi MA and Mohammadikhanaposhti M and Larijani B and Dadgar A and Mahdavic M}, title = {Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations}, journal = {Bioorganic Chemistry}, volume = {166}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Pourmand SMH AU - Halimi M AU - Alaeddini A AU - Akbari M AU - Noori M AU - Mojtabavi S AU - Faramarzi MA AU - Mohammadikhanaposhti M AU - Larijani B AU - Dadgar A AU - Mahdavic M TI - Chroman, Pyridine, and Coumarin in a New Fused Scaffold As Α-Glucosidase Inhibitor: Synthesis of New Derivatives, in Vitro, and in Silico Evaluations JO - Bioorganic Chemistry VL - 166 IS - SP - EP - PY - 2025 ER -

Science Communicator Platform

Authors

Abstract