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Evaluation of Potential Biomarkers of Exposure to Crystalline Silica: A Case Study in an Insulator Manufacturer Publisher Pubmed



Mohammadi H1 ; Farhang Dehghan S2 ; Tahamtan A3, 4 ; Golbabaei F5
Authors
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Authors Affiliations
  1. 1. Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Occupational Health, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Department of Occupational Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Toxicology and Industrial Health Published:2018


Abstract

The purpose of this study was to examine the potential determinants of serum neopterin, malondialdehyde (MDA), and erythrocyte glutathione (GSH) as potential markers of oxidative stress, resulting in cellular immune response to inhaled silica particles. This descriptive analytical study was conducted on two groups of exposed workers (n = 55) and unexposed office workers (n = 38) of an insulator manufacturing plant. The sampling of airborne silica in the breathing zone of participants was done on the basis of the National Institute for Occupational Safety and Health Method 7601. The blood samples were analyzed by high performance liquid chromatography to determine the level of serum neopterin. A ZellBio GmbH assay kit was used for the quantitative assays of GSH and MDA on the basis of the colorimetric assay. The results of this study show that the measurements of serum neopterin, MDA, and GSH can be considered as potential biological markers of silica exposure for undertaking further comprehensive studies in this area. © 2018, © The Author(s) 2018.
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Experts (# of related papers)
Mehdi Yaseri (1)
Farideh Golbabaei (1)