Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial

Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial Publisher Pubmed

Abedini R¹ ; Sasani P² ; Mahmoudi HR¹ ; Nasimi M¹ ; Teymourpour A³ ; Shadlou Z²

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1. Autoimmune Bullous Disease Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. School of Public Health, Tehran University of Medical Sciences, Iran

Source: Burns Published:2018

Abstract

Background: Keloids and hypertrophic scars are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems. Methods: In this randomized controlled trial, with a paired design, 50 patients with 2 or more keloids were included. In the control group (50 lesions), intralesional triamcinolone acetonide (40 mg/mL) was injected at three-week intervals for a total of 18 weeks. In the other group (50 lesions), lesions were treated by verapamil (2.5 mg/mL) with the same therapeutic sessions. Scar evaluation at each stage and at the end of 3 months follow up was done by serial photographic records as well as by Vancouver Scar Scale (VSS). Results: Mean zero VSS scores were achieved with only triamcinolone in respect of scar height (week 15th) and pliability (week 15th). No therapeutic event (parameter = 0) or significant improvement was seen in verapamil group. Conclusion: Our results did not support verapamil's capability in treatment of keloid nor hypertrophic scars. © 2018 Elsevier Ltd and ISBI

Style	Citing Format
MLA	Abedini R, et al.. "Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial." Burns, vol. 44, no. 6, 2018, pp. 1482-1488.
APA	Abedini R, Sasani P, Mahmoudi HR, Nasimi M, Teymourpour A, Shadlou Z (2018). Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial. Burns, 44(6), 1482-1488.
Chicago	Abedini R, Sasani P, Mahmoudi HR, Nasimi M, Teymourpour A, Shadlou Z. "Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial." Burns 44, no. 6 (2018): 1482-1488.
Harvard	Abedini R et al. (2018) 'Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial', Burns, 44(6), pp. 1482-1488.
Vancouver	Abedini R, Sasani P, Mahmoudi HR, Nasimi M, Teymourpour A, Shadlou Z. Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial. Burns. 2018;44(6):1482-1488.
BibTex	@article{ author = {Abedini R and Sasani P and Mahmoudi HR and Nasimi M and Teymourpour A and Shadlou Z}, title = {Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial}, journal = {Burns}, volume = {44}, number = {6}, pages = {1482-1488}, year = {2018} }
RIS	TY - JOUR AU - Abedini R AU - Sasani P AU - Mahmoudi HR AU - Nasimi M AU - Teymourpour A AU - Shadlou Z TI - Comparison of Intralesional Verapamil Versus Intralesional Corticosteroids in Treatment of Keloids and Hypertrophic Scars: A Randomized Controlled Trial JO - Burns VL - 44 IS - 6 SP - 1482 EP - 1488 PY - 2018 ER -

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