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Design and Characterization of Electroactive Gelatin Methacrylate Hydrogel Incorporated With Gold Nanoparticles Empowered With Parahydroxybenzaldehyde and Curcumin for Advanced Tissue Engineering Applications Publisher Pubmed



Barabadi Z1, 2 ; Bahmani A1 ; Jalalimonfared M3 ; Ashrafizadeh M4, 5, 6, 7 ; Rashtbar M8 ; Sharifi E1, 2, 9 ; Tian H10
Authors
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Authors Affiliations
  1. 1. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of General Surgery, Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Guangdong, Shenzhen, 518055, China
  5. 5. International Association for Diagnosis and Treatment of Cancer, Guangdong, Shenzhen, 518055, China
  6. 6. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
  7. 7. Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, Jinan, 250000, China
  8. 8. Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  10. 10. School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China

Source: Journal of Materials Science: Materials in Medicine Published:2024


Abstract

Electroconductive polymers are the materials of interest for the fabrication of electro-conductive tissues. Metal ions through the redox systems offer polymers with electrical conductivity. In this study, we processed a gelatin methacrylate (GelMA) network with gold nanoparticles (GNPs) through a redox system with parahydroxybenzaldehyde (PHB) or curcumin to enhance its electrical conductivity. Induction of the redox system with both PHB and curcumin into the GelMA, introduced some new functional groups into the polymeric network, as it has been confirmed by H-NMR and FTIR. These new bonds resulted in higher electro-conductivity when GNPs were added to the polymer. Higher electroactivity was achieved by PHB compared to the curcumin-induced redox system, and the addition of GNPs without redox system induction showed the lowest electroactivity. MTT was used to evaluate the biocompatibility of the resultant polymers, and the PHB-treated hydrogels showed higher proliferative effects on the cells. The findings of this study suggest that the introduction of a redox system by PHB in the GelMA network along with GNPs can contribute to the electrochemical properties of the material. This electroactivity can be advantageous for tissue engineering of electro-conductive tissues like cardiac and nervous tissues. Graphical Abstract: (Figure presented.) © The Author(s) 2024.
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