Evaluating Socket Management With Clot-Retaining Collagen: A Single-Blind Randomized Clinical Trial Publisher



Mirmohammadsadeghi H¹ ; Kadkhodazadeh M² ; Bakhtiari F³ ; Mighani F^{4, 5} ; Bakhtiari Z⁶ ; Dabiri N⁷
Source: Journal of Dental Materials and Techniques Published:2025

Abstract

Objective: The present single-blind split-mouth randomized clinical trial aimed to evaluate the effect of socket management with clot-retaining collagen (Collacone®) on post-extraction socket healing. Methods: Sixteen participants (20 pairs of sockets) were included, and underwent bilateral premolar extraction using an atraumatic extraction technique. For each patient, one socket remained empty, whereas Collacone® was placed on the contralateral side. Both sockets were sutured, and buccolingual (BL) and mesiodistal (MD) socket widths were measured. Furthermore, pain, comfort, bleeding, and swelling levels were recorded at baseline and two and four weeks after extraction. Data were analyzed with the repeated measures ANOVA (α=0.05). Results: The study included 11 females and five males with an average age of 32±5 years. The MD and BL widths of the extraction sockets decreased significantly in the experimental and control groups over 4 weeks (P<0.001). The BL and MD width of the extraction sockets were comparable between the groups at all time points (P>0.05). No significant differences were found in pain, comfort, bleeding, and swelling levels between the groups at 2 and 4 weeks postextraction (P>0.05). Conclusions: The application of Collacone® following atraumatic tooth extraction does not offer any advantages in preserving socket dimensions and reducing patients’ pain, comfort, bleeding, and swelling levels in healthy young individuals. © 2025 Mashhad University of Medical Sciences.