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Extra Corporeal Photochemotherapy in Steroid Refractory Graft Versus Host Disease: A Review of Guidelines and Recommendations Publisher Pubmed



Mohammadi S1 ; Malek Mohammadi A1 ; Norooznezhad AH1 ; Heshmati F2 ; Alimoghaddam K1 ; Ghavamzadeh A1
Authors
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Authors Affiliations
  1. 1. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Transfusion Medicine Units, Cochin Hospital, Paris, France

Source: Transfusion and Apheresis Science Published:2017


Abstract

Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic hematopoietic stem cells transplantation (HSCT) and leads to morbidity and mortality in transplanted patients. Corticosteroids are the standard therapy for GVHD; however, a great number of patients will not respond sufficiently and others will be significantly affected by adverse effects of steroids. Extracorporeal photochemotherapy (ECP), as one of the numerous second line therapies, through modulation of immune cells may improves GVHD affected organ function in steroid-refractory forms. Considering to widespread utilization of ECP as a therapeutic strategy, we performed review on current literature of ECP, regarding the treatment strategies, monitoring protocols and technical aspects in chronic and acute GVHD. © 2017 Elsevier Ltd