Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator

Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator Publisher

Nazari A¹ ; Alavimajd H¹ ; Shakeri N¹ ; Bakhshandeh M² ; Faghihzadeh E¹ ; Marzbani H^{3, 4}

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1. Department of Biostatistics, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Biomedical Engineering and Medical Physics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Neural Engineering Research Center, Noorafshar Hospital, Tehran, Iran

Source: Basic and Clinical Neuroscience Published:2019

Abstract

Introduction: In recent years, brain functional connectivity studies are extended using the advanced statistical methods. Functional connectivity is identified by synchronous activation in a spatially distinct region of the brain in resting-state functional Magnetic Resonance Imaging (MRI) data. For this purpose there are several methods such as seed-based correlation analysis based on temporal correlation between different Regions of Interests (ROIs) or between brain’s voxels of prior seed. Methods: In the current study, test-retest Resting State functional MRI (rs-fMRI) data of 21 healthy subjects were analyzed to predict second replication connectivity map using first replication data. A potential estimator is “raw estimator” that uses the first replication data from each subject to predict the second replication connectivity map of the same subject. The second estimator, “mean estimator” uses the average of all sample subjects' connectivity to estimate the correlation map. Shrinkage estimator is made by shrinking raw estimator towards the average connectivity map of all subjects' first replicate. Prediction performance of the second replication correlation map is evaluated by Mean Squared Error (MSE) criteria. Results: By the employment of seed-based correlation analysis and choosing precentral gyrus as the ROI over 21 subjects in the study, on average MSE for raw, mean and shrinkage estimator were 0.2169, 0.1118, and 0.1103, respectively. Also, percent reduction of MSE for shrinkage and mean estimator in comparison with raw estimator is 49.14 and 48.45, respectively. Conclusion: Shrinkage approach has the positive effect on the prediction of functional connectivity. When data has a large between session variability, prediction of connectivity map can be improved by shrinking towards population mean. © 2019 Iran University of Medical Sciences. All rights reserved.

2. A Novel Approach for Extracting Functional Brain Networks Involved in Mesial Temporal Lobe Epilepsy Based on Self Organizing Maps, Informatics in Medicine Unlocked (2022)

3. Classification of Early-Mci Patients From Healthy Controls Using Evolutionary Optimization of Graph Measures of Resting-State Fmri, for the Alzheimer’S Disease Neuroimaging Initiative, PLoS ONE (2022)

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Style	Citing Format
MLA	Nazari A, et al.. "Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator." Basic and Clinical Neuroscience, vol. 10, no. 2, 2019, pp. 147-156.
APA	Nazari A, Alavimajd H, Shakeri N, Bakhshandeh M, Faghihzadeh E, Marzbani H (2019). Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator. Basic and Clinical Neuroscience, 10(2), 147-156.
Chicago	Nazari A, Alavimajd H, Shakeri N, Bakhshandeh M, Faghihzadeh E, Marzbani H. "Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator." Basic and Clinical Neuroscience 10, no. 2 (2019): 147-156.
Harvard	Nazari A et al. (2019) 'Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator', Basic and Clinical Neuroscience, 10(2), pp. 147-156.
Vancouver	Nazari A, Alavimajd H, Shakeri N, Bakhshandeh M, Faghihzadeh E, Marzbani H. Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator. Basic and Clinical Neuroscience. 2019;10(2):147-156.
BibTex	@article{ author = {Nazari A and Alavimajd H and Shakeri N and Bakhshandeh M and Faghihzadeh E and Marzbani H}, title = {Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator}, journal = {Basic and Clinical Neuroscience}, volume = {10}, number = {2}, pages = {147-156}, year = {2019} }
RIS	TY - JOUR AU - Nazari A AU - Alavimajd H AU - Shakeri N AU - Bakhshandeh M AU - Faghihzadeh E AU - Marzbani H TI - Research Paper: Prediction of Brain Connectivity Map in Resting-State Fmri Data Using Shrinkage Estimator JO - Basic and Clinical Neuroscience VL - 10 IS - 2 SP - 147 EP - 156 PY - 2019 ER -

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