Drug Repositioning: A Review

Drug Repositioning: A Review

Jafari RM^{1, 2} ; Sheibani M¹ ; Nezamoleslami S¹ ; Shayesteh S¹ ; Jand Y¹ ; Dehpour AR^{1, 2}

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1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Iranian Medical Council Published:2018

Abstract

Drug repositioning is one of the common strategies of new indications and therapeutic targets for already known drugs. Drug repositioning is known by various names in textbooks such as drug re-proposing, re-profiling, re-tasking and therapeutic switching. Drugs may act through multiple molecular targets. Although perhaps designed for specificity, modulate several targets. This Poly-pharmacology may also be essential for efficacy. This off-targets may also lead to side-effect. Repositioning vs traditional drug discovery reduces time, reduces risk, and reduces cost. Bleeding disorder observation of aspirin (a wonder drug) over the years (1891) was made repeatedly leading to the suggestion by Craven (1953) that aspirin might be used for the prevention of thrombosis. The historically unintentional, serendipitous, or constrained research effort is now being replaced by systematic, high-throughput and rational pursuit of new therapeutic uses for marketed drugs, drugs in development, or as a drug salvaging strategy. © 2020, Journal of Iranian Medical Council.

Style	Citing Format
MLA	Jafari RM, et al.. "Drug Repositioning: A Review." Journal of Iranian Medical Council, vol. 1, no. 1, 2018, pp. 7-10.
APA	Jafari RM, Sheibani M, Nezamoleslami S, Shayesteh S, Jand Y, Dehpour AR (2018). Drug Repositioning: A Review. Journal of Iranian Medical Council, 1(1), 7-10.
Chicago	Jafari RM, Sheibani M, Nezamoleslami S, Shayesteh S, Jand Y, Dehpour AR. "Drug Repositioning: A Review." Journal of Iranian Medical Council 1, no. 1 (2018): 7-10.
Harvard	Jafari RM et al. (2018) 'Drug Repositioning: A Review', Journal of Iranian Medical Council, 1(1), pp. 7-10.
Vancouver	Jafari RM, Sheibani M, Nezamoleslami S, Shayesteh S, Jand Y, Dehpour AR. Drug Repositioning: A Review. Journal of Iranian Medical Council. 2018;1(1):7-10.
BibTex	@article{ author = {Jafari RM and Sheibani M and Nezamoleslami S and Shayesteh S and Jand Y and Dehpour AR}, title = {Drug Repositioning: A Review}, journal = {Journal of Iranian Medical Council}, volume = {1}, number = {1}, pages = {7-10}, year = {2018} }
RIS	TY - JOUR AU - Jafari RM AU - Sheibani M AU - Nezamoleslami S AU - Shayesteh S AU - Jand Y AU - Dehpour AR TI - Drug Repositioning: A Review JO - Journal of Iranian Medical Council VL - 1 IS - 1 SP - 7 EP - 10 PY - 2018 ER -

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