Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population

Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population Publisher Pubmed

Rogo LD^{1, 2} ; Rezaei F^{1, 3} ; Marashi SM¹ ; Yekaninejad MS⁴ ; Naseri M^{1, 3} ; Ghavami N^{1, 3} ; Mokhtariazad T^{1, 3}

Show Affiliations

1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran
2. Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University Kano, Kano, Nigeria
3. National Influenza, Center Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Virology Published:2016

Abstract

Increased blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A/H3N2 virus infection. The study was aimed to investigate the polymorphisms of IL-1β, IL-10, IL-17, and IL-28 genes to find the possibility of their association with the clinical outcome of influenza A/H3N2 virus infection among the infected patients in Iran. This is a Case-Control study in which influenza A/H3N2 virus positive confirmed with real-time PCR were the cases. DNA samples from groups were genotyped for polymorphisms in rs16944 (IL-1β), rs1800872 (IL-10), rs2275913 (IL-17), and rs8099917 (IL-28). Confidence interval (95%CI) and Odds ratio (OR) were calculated. IL-17 rs2275913 (GG and AG) were associated with risk of infection with that were statistically significant (P < 0.05, OR = 2.08–2.94). IL-1β (rs16944) (GG) was associated with reduced risk of infection (P < 0.01, OR = 0.46). Genotype GG and GT of IL-10 (rs1800872) were associated with increased risk of infection with influenza A/H3N2 virus (P < 0.05, OR = 2.04–2.58). In addition, IL-28 (rs8099917) genotypes GG (P < 0.05, OR = 0.49) and TG (P < 0.05, OR = 0.59) were associated with reduced risk of ILI symptom while genotype TT (P < 0.01, OR = 4.31) was associated with increased risk of ILI symptom. The results of this study demonstrated that polymorphisms of genes involved in the inflammatory and anti-inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus. Thorough insight on host immune response at the time of influenza A virus infection is required to ensure adequate patient care in the case of feature outbreaks. J. Med. Virol. 88:2078–2084, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

2. Emerging Cytokines in Allergic Airway Inflammation: A Genetic Update, Current Immunology Reviews (2016)

3. Interindividual Immunogenic Variants: Susceptibility to Coronavirus, Respiratory Syncytial Virus and Influenza Virus, Reviews in Medical Virology (2021)

Experts (# of related papers)

Nima Rezaei (1)

Farhad Rezaei (1)

Style	Citing Format
MLA	Rogo LD, et al.. "Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population." Journal of Medical Virology, vol. 88, no. 12, 2016, pp. 2078-2084.
APA	Rogo LD, Rezaei F, Marashi SM, Yekaninejad MS, Naseri M, Ghavami N, Mokhtariazad T (2016). Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population. Journal of Medical Virology, 88(12), 2078-2084.
Chicago	Rogo LD, Rezaei F, Marashi SM, Yekaninejad MS, Naseri M, Ghavami N, Mokhtariazad T. "Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population." Journal of Medical Virology 88, no. 12 (2016): 2078-2084.
Harvard	Rogo LD et al. (2016) 'Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population', Journal of Medical Virology, 88(12), pp. 2078-2084.
Vancouver	Rogo LD, Rezaei F, Marashi SM, Yekaninejad MS, Naseri M, Ghavami N, et al.. Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population. Journal of Medical Virology. 2016;88(12):2078-2084.
BibTex	@article{ author = {Rogo LD and Rezaei F and Marashi SM and Yekaninejad MS and Naseri M and Ghavami N and Mokhtariazad T}, title = {Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population}, journal = {Journal of Medical Virology}, volume = {88}, number = {12}, pages = {2078-2084}, year = {2016} }
RIS	TY - JOUR AU - Rogo LD AU - Rezaei F AU - Marashi SM AU - Yekaninejad MS AU - Naseri M AU - Ghavami N AU - Mokhtariazad T TI - Seasonal Influenza A/H3n2 Virus Infection and Il-1Β, Il-10, Il-17, and Il-28 Polymorphisms in Iranian Population JO - Journal of Medical Virology VL - 88 IS - 12 SP - 2078 EP - 2084 PY - 2016 ER -

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