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Effect of a Short-Term Lifestyle Modification Program on Quality of Life, Anthropometric Characteristics and Cd4+T Cell Count of Hiv Infected Patients in Tehran/Iran: A Randomized Controlled Trial Publisher Pubmed



Ghayomzadeh M1 ; Etesami MS2 ; Earnest CP3 ; Rezaei S1 ; Navalta JW4 ; Taj L5 ; Seyedalinaghi S5 ; Mohraz M5 ; Gharakhanlou R1 ; Voltarelli FA6
Authors
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Authors Affiliations
  1. 1. Department of Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
  2. 2. Faculty of Psychology and Education, University of Tehran, Iran
  3. 3. Exercise and Sport Nutrition Laboratory, Texas A&M University, College Station, TX, United States
  4. 4. Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, United States
  5. 5. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Graduation Program of Health Sciences, Faculty of Medicine, Federal University of Mato, Grosso, Cuiaba, Brazil

Source: Explore Published:2019


Abstract

Context: Increasing physical activity and promoting healthy behaviors may play a key role in reducing the adverse effects of antiretroviral therapy and HIV. Objective: This study investigated the effects of an 8-week lifestyle modification program (LMP) on quality of life, anthropometric characteristics and CD4+T cell count of people living with HIV (PLWH). Methods: Thirty PLWH taking ART were randomly assigned to a lifestyle modification program (LMP) (n = 15) or standard care control (CON) group (n = 15). All volunteers underwent body composition, CD4+T cell count measurement and quality of life assessments at the beginning and end of a two-month experimental period. Results: At follow-up, we observed a significant increase in CD4+T cell count (117.52 cells/mm3; 95% CI, 36.59–198.45) and all subscales and total quality of life score (Short-Form 36 (SF-36) in the LMP group. While we did not observe a significant change in body composition for the LMP group, we did observe a significant increase in body fat (1.75%; 95% CI, 0.15, 2.33) and a reduction in lean body mass (−1.26; 95% CI, −1.26, −2.39) for the CON group. Conclusion: A LMP can be safely used as an effective intervention for improving quality of life and immune competence of PLWH who lack time to participate in a structured exercise regimen. Trial registration: IRCT 201604034076N18. Registered: 2016-05-05.web address of TRIAL: en.search.irct.ir/trial/4262 © 2019 Elsevier Inc.
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