Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]

Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C] Publisher

Saadatjoo N¹ ; Javaheri M^{1, 2} ; Saemian N² ; Amini M³

Show Affiliations

1. Department of Organic Chemistry, Faculty of Chemistry, Semnan University, PO Box: 35131-19111, Semnan, Iran
2. Applied Radiations Research School, Nuclear Science and Technology Research Institute, P.O.Box: 11365-3486, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016

Abstract

Quetiapine is one of the most widely used antipsychotic drug which acts as an antagonist for multiple neurotransmitter receptor sites. 2-[2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy]ethanol (quetiapine) labeled with carbon-14 in 11-position has been synthesized as part of a 5-step sequence from anthranilic acid-[carboxy-14C]. We have presented a convenient synthetic pathway for labeling of quetiapine with carbon-14 by using one-pot procedures from a key thiazepin-11(10H)-one-[11-14C] by good radiochemical yield. And also isoclotiapine[11-14C], and 10-(4-methylpiperazin-1-yl)pyrido[4,3-b][1,4]benzothiazepine[10-14C], synthesized according to this route. © 2016, Akademiai Kiado, Budapest, Hungary.

Style	Citing Format
MLA	Saadatjoo N, et al.. "Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]." Journal of Radioanalytical and Nuclear Chemistry, vol. 310, no. 1, 2016, pp. 433-439.
APA	Saadatjoo N, Javaheri M, Saemian N, Amini M (2016). Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]. Journal of Radioanalytical and Nuclear Chemistry, 310(1), 433-439.
Chicago	Saadatjoo N, Javaheri M, Saemian N, Amini M. "Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]." Journal of Radioanalytical and Nuclear Chemistry 310, no. 1 (2016): 433-439.
Harvard	Saadatjoo N et al. (2016) 'Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]', Journal of Radioanalytical and Nuclear Chemistry, 310(1), pp. 433-439.
Vancouver	Saadatjoo N, Javaheri M, Saemian N, Amini M. Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]. Journal of Radioanalytical and Nuclear Chemistry. 2016;310(1):433-439.
BibTex	@article{ author = {Saadatjoo N and Javaheri M and Saemian N and Amini M}, title = {Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C]}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {310}, number = {1}, pages = {433-439}, year = {2016} }
RIS	TY - JOUR AU - Saadatjoo N AU - Javaheri M AU - Saemian N AU - Amini M TI - Synthesis of 11-14C-Quetiapine, 11-14C-Isoclotiapine and 10-(4-Methylpiperazin-1-Yl)Pyrido[4,3-B][1,4]Benzothiazepine[10-14C] JO - Journal of Radioanalytical and Nuclear Chemistry VL - 310 IS - 1 SP - 433 EP - 439 PY - 2016 ER -

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