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Assessment of Dietary Intake and Its Inflammatory Potential in Persons With Pediatric-Onset Multiple Sclerosis Publisher Pubmed



Bitarafan S1, 2 ; Zhu F1 ; Mirza A1 ; Bernstein CN3 ; Van Domselaar G5, 6 ; Marrie RA4 ; Yeh EA7 ; Zhao Y1 ; Banwell B8 ; Waubant E9 ; Tremlett H1
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine (Neurology), University of British Columbia and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada
  2. 2. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Internal Medicine and University of Manitoba IBD Clinical and Research Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  4. 4. Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  5. 5. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
  6. 6. Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  7. 7. Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, Division of Neuroscience and Mental Health, SickKids Research Institute, University of Toronto, Toronto, Canada
  8. 8. Division of Child Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, United States
  9. 9. Weill Institute for Neurosciences, Neurology Department, University of California, San Francisco, United States

Source: Multiple Sclerosis and Related Disorders Published:2024


Abstract

Objective: To compare diet and the modified dietary inflammatory index (mDII) between individuals with pediatric-onset multiple sclerosis (PoMS), monophasic acquired demyelinating syndromes (monoADS), and controls. Methods: The association between diet, mDII, and disease status was examined in 131 individuals with PoMS/monoADS/controls (38/45/48) using logistic regression. Results: The associations between diet and PoMS were modest, reaching significance for whole grain intake (adjusted odds ratio, aOR=0.964, 95 % confidence intervals, CI:0.934–0.995) but not mDII (aOR=1.20, 95 %CI:0.995–1.46) versus controls. No findings for monoADS reached significance versus controls. Conclusions: Individuals with PoMS, but not monoADS, had lower dietary whole grain intake than controls. © 2024 The Author(s)
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