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Catalyst-Free Three-Component Synthesis of 2-Amino-4,6-Diarylpyridine-3-Carbonitriles Under Solvent-Free Conditions Publisher



Sayahi MH1 ; Saghanezhad SJ2 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Payame Noor University, P. O. Box, Tehran, 19395-3697, Iran
  2. 2. ACECR-Production Technology Research Institute, P. O. Box, Ahvaz, 61396-84689, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, P. O. Box, Tehran, 14117-13137, Iran

Source: Chemistry of Heterocyclic Compounds Published:2019


Abstract

[Figure not available: see fulltext.] A novel efficient one-pot synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles is described. Method involves heating the mixture of an acetophenone oxime, aldehyde, and malononitrile without any catalyst under solvent-free conditions to give the title compounds in good to high yields. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.