Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Inflammation, Oxidative Stress, Angiogenesis, and Apoptosis in the Pathophysiology of Endometriosis: Basic Science and New Insights Based on Gene Expression Publisher Pubmed



Samimi M1 ; Pourhanifeh MH2 ; Mehdizadehkashi A1 ; Eftekhar T3 ; Asemi Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Reproductive Health Research Center, Tehran University of Medical Science, Tehran, Iran

Source: Journal of Cellular Physiology Published:2019


Abstract

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. However, its exact physiopathology is not well known. Recent studies have shown the possible roles of inflammation along with oxidative stress. Additionally, angiogenesis and apoptosis dysregulation contribute to endometriosis pathophysiology. Therapeutic strategies and continuing attempts, to conquer endometriosis should be done regarding molecular signaling pathways. Thus, the present review summarizes current studies and focuses on molecular mechanisms. © 2019 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. Apoptotic Functions of Micrornas in Pathogenesis, Diagnosis, and Treatment of Endometriosis, Cell and Bioscience (2020)
2. Oxidative Stress Statues in Serum and Follicular Fluid of Women With Endometriosis, Cell Journal (2016)
3. Non-Hormonal Therapy for Endometriosis Based on Angiogenesis, Oxidative Stress and Inflammation, International Journal of Fertility and Sterility (2024)
4. The Effect of Acetylsalicylic Acid on Pain and Recurrence of Endometriosis After Surgery: A Randomized Controlled Trial, Journal of Endometriosis and Pelvic Pain Disorders (2021)
5. Evaluation of Apoptosis and Angiogenesis in Ectopic and Eutopic Stromal Cells of Patients With Endometriosis Compared to Non-Endometriotic Controls, BMC Women's Health (2020)
6. Controlling Semi-Invasive Activity of Human Endometrial Stromal Cells by Inhibiting Nf-Κb Signaling Pathway Using Aloe-Emodin and Aspirin, Journal of Reproduction and Infertility (2021)
7. Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective, Pathology Research and Practice (2023)
8. Nf-Κb As the Main Node of Resistance to Receptor Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer, Tumor Biology (2017)
Experts (# of related papers)
View all Related Experts
Ashraf Moini (8)
Ladan Kashani (3)
Other Related Docs
9. Apoptosis Induction of Human Endometriotic Epithelial and Stromal Cells by Noscapine, Iranian Journal of Basic Medical Sciences (2016)
10. The Landscape of Non-Coding Rnas in the Immunopathogenesis of Endometriosis, Frontiers in Immunology (2023)
11. A Randomized Exploratory Trial to Assess the Effects of Resveratrol on Vegf and Tnf-Α 2 Expression in Endometriosis Women, Journal of Reproductive Immunology (2021)
12. Astaxanthin Ameliorates Inflammation, Oxidative Stress, and Reproductive Outcomes in Endometriosis Patients Undergoing Assisted Reproduction: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial, Frontiers in Endocrinology (2023)
13. Ovarian Tissue Culture in the Presence of Vegf and Fetuin Stimulates Follicle Growth and Steroidogenesis, Journal of Endocrinology (2017)
14. The Role of Quercetin for the Treatment of Endometriosis and Endometrial Cancer: A Comprehensive Review, Current Medicinal Chemistry (2025)
15. Comparison of B-Cell Lymphoma 2 (Bcl-2) Expression in Disordered Proliferative Endometrium and Simple Endometrial Hyperplasia; [Comparacion De La Expresion Del Linfoma De Celulas B2 (Bcl-2) En El Endometrio Proliferativo Desordenado Y La Hiperplasia Endometrial Simple], Revista Espanola de Patologia (2024)
16. Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis, Iranian Journal of Allergy# Asthma and Immunology (2021)
17. Soluble Cd44 Concentration in the Serum and Peritoneal Fluid Samples of Patients With Different Stages of Endometriosis, Archives of Gynecology and Obstetrics (2015)
18. Evaluating Hematological Parameters in Women With Endometriosis, Journal of Obstetrics and Gynaecology (2021)
19. Prevalence of High-Risk Human Papillomavirus Infection in Women With Ovarian Endometriosis, Journal of Obstetrics and Gynaecology Research (2017)
20. Calligonum Comosum (Escanbil) Extract Exerts Anti-Angiogenic, Anti-Proliferative and Anti-Inflammatory Effects on Endometriotic Lesions, Journal of Ethnopharmacology (2019)
21. Gene Expression Analysis Signifies the Association of Inflammatory Proteins With the Development of Endometriosis, Gene Reports (2020)