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The Effect of Preoperative Pentoxifylline on Postoperative Pain and Development of Secondary Hyperalgesia in Patients Undergoing Laparoscopic Appendectomy: A Randomized, Double-Blind, Placebo-Controlled Trial Study Publisher Pubmed



Nazemi S1 ; Taherian A2 ; Khajeh M3 ; Shahrestanaki E4 ; Jafarpour M5 ; Abdolalizadeh A5 ; Sahebkar M5, 6
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
  2. 2. Department of Nursing, School of Nursing, Islamic Azad University, Kashmar, Iran
  3. 3. Department of Surgery and Orthopedics, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
  6. 6. Department of Social Medicine, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

Source: Pain Practice Published:2021


Abstract

Background: After surgery and loss of anesthetic effect, postoperative pain can annoy the patient and affect patient satisfaction with treatment. This study was aimed at evaluating the effect of preoperative pentoxifylline (PTX) on postoperative pain and development of secondary hyperalgesia in patients undergoing laparoscopic appendectomy (LA). Methods: This randomized, double-blind, placebo-controlled clinical trial study was conducted on 91 eligible subjects with acute appendicitis referred to Shahid Beheshti hospital of Sabzevar, Iran, in 2018. The intervention and control groups were administered with a single oral dose of PTX (10 mg/kg) and placebo an hour before surgery, respectively. Postoperative pain was measured within 24 hours after surgery using a VAS, and the area of secondary hyperalgesia was measured 24 hours after surgery using the Stubhaug et al. method. Results: The mean age of the subjects was 26.74 ± 9.99 years, and 57.14% were female. Pain intensity during rest was significantly greater in the control group as compared to the PTX group 24 hours after surgery (VAS scores 2.19 ± 0.49 and 3.13 ± 0.66, respectively; P < 0.001). Moreover, pain intensity during cough was substantially lower in the PTX group compared with the control group 24 hours after surgery (VAS scores 2.65 ± 1.90 and 4.10 ± 2.60, respectively; P = 0.003 in turn). The dynamic hyperalgesia was significantly greater in the control group as compared with the PTX group (3.80 ± 1.82 and 7.43 ± 2.38, respectively; P < 0.001). Conclusions: Findings suggest that oral administration of PTX 1 hour before surgery in patients undergoing LA can reduce postoperative pain in patients and prevent secondary hyperalgesia at a surgical site. © 2020 World Institute of Pain
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2. Trends and Levels of the Global, Regional, and National Burden of Appendicitis Between 1990 and 2021: Findings From the Global Burden of Disease Study 2021, The Lancet Gastroenterology and Hepatology (2024)
3. Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain, Fundamental and Clinical Pharmacology (2017)
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