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Production Of68ga-Citrate Based on a Sno2generator for Short-Term Turpentine Oil-Induced Inflammation Imaging in Rats Publisher Pubmed



Mirzaei A1 ; Jalilian AR1 ; Akhlaghi M2 ; Beiki D2
Authors
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Authors Affiliations
  1. 1. Nuclear Science and Technology Research Institute, Tehran, 141551339, Iran
  2. 2. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Radiopharmaceuticals Published:2016


Abstract

Introduction: Gallium-68 citrate has been successfully applied in the PET imaging of infections and inflammation in some centers; however further evaluation of the tracer in inflammation models is of great importance. Methods:68Ga-citrate prepared from [68Ga]GaCl3(eluted form an SnO2based68Ge/68Ga generator) and sodium citrate at optimized conditions followed by quality control tests was injected to normal and turpentine-oil induced rats PET/CT imaging studies up to 290 min. Results:68Ga-citrate was prepared with acceptable radiochemical purity (>99 ITLC, >99% HPLC), specific activity (28-30 GBq/mM), chemical purity (Sn, Fe <0.3 ppm; Zn<0.2 ppm) in 15 min at 50°C. PET/CT imaging of the tracer demonstrated early detection of inflamed site in animal models in 60-80 min. Conclusion: This study demonstrated possible early detection of inflammation foci in vivo using 68Ga-citrate prepared using commercially available68Ge/68Ga generators for PET imaging. © 2016 Bentham Science Publishers.